Recombinant Factor VIIa (NovoSeven) on Restoring Coagulation Activation
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The purpose of the study is to compare the effects of recombinant factor VIIa (NovoSeven) on restoring coagulation activation between patients with hemophilia A and antibodies to factor VIII and normal subjects (controls) by use of an in vivo method.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Adult patients with hemophilia A and current antibodies to factor VIII -
Severe liver failure
Any other severe co-morbidity (including diabetes mellitus, renal failure, cancer, septicemia, disseminated intravascular coagulation, crush injury)
Exposure to other haemostatic drugs during the previous 7 days
Hypersensitivity to hamster, mouse or bovine proteins
Known or suspected allergy to NovoSeven or any of its components