Comparison of Two Different Dosages of Low-molecular Weight Heparin in Cancer Patients
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In a prospective, randomized, double-blind trial, the effects of two different dosages of LMWH (5000 anti-Xa U od sc and 10 000 anti-Xa U od sc daily) on markers of hemostatic system and thrombin generation will be investigated in non-surgical cancer patients will be investigated.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients (> 18 years) with active cancer and at least one of the following indications for thromboprophylaxis with LMWH:
History of VTE
Heart failure (NYHA class III or IV)
Indication for LMWH or UFH at therapeutic dosages
Treatment with antithrombotics (vitamin K antagonists, acetylsalicylic acid, clopidogrel) for reasons other than prevention of VTE (e.g. atrial fibrillation, myocardial infarction)
Contraindication for the treatment with LMWH
Major surgery within the last 4 weeks; minor surgery within the last week
Thrombocytopenia (< 100.000/μl)
Prolonged prothrombin time
Prolonged activated partial thromboplastin time (aPTT)