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The Combined Effect of 2,3-Dimercaptosuccinic Acid and Multi-Nutrients on Children in Lead Poisoning

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ClinicalTrials.gov Identifier: NCT00374894
Recruitment Status : Completed
First Posted : September 12, 2006
Last Update Posted : September 12, 2006
Information provided by:
China Medical University, China

Brief Summary:
Lead poisoning remains a common disease among children despite successful public health efforts that reduced its prevalence.Our study was designed to test the hypothesis that lead-poisoning children (BLLs:100-440µg/L) who were given DMSA and multi-nutrients would have a greater fall than children of other groups at 12 weeks of follow-up.

Condition or disease Intervention/treatment
Lead Poisoning Drug: 2,3-dimercaptosuccinic acid

Study Type : Observational
Estimated Enrollment : 500 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Study Start Date : March 2004
Estimated Study Completion Date : August 2004

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U.S. FDA Resources

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Ages Eligible for Study:   3 Years to 6 Years   (Child)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Initial BLLs 100-440µg/L
  • Age 3-6y
  • No more than two main residences
  • House cleaned (no lead contaminated)
  • Normal intake history and physical

Exclusion Criteria:

  • Chelation in the past 12 weeks
  • Concomitant Fe deficiency(ferritin<16ng/ml)
  • Hemoglobin<10.5g/dL
  • Medications affecting mineral metabolism

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00374894

China, Liaoning
China Medical University
Shenyang, Liaoning, China, 110001
Sponsors and Collaborators
China Medical University, China
Study Director: Jin Ya ping, professor Department of Environmental and Occupational Health

CDC.Preventing lead poisoning in young children[R]. U.D.Dept of health and Human services 1991:1.

ClinicalTrials.gov Identifier: NCT00374894     History of Changes
Other Study ID Numbers: 20032063 - 2001102049
First Posted: September 12, 2006    Key Record Dates
Last Update Posted: September 12, 2006
Last Verified: April 2004

Keywords provided by China Medical University, China:
2,3-dimercaptosuccinic acid
Blood Lead Levels

Additional relevant MeSH terms:
Lead Poisoning
Chemically-Induced Disorders
Protective Agents
Physiological Effects of Drugs
Chelating Agents
Sequestering Agents
Molecular Mechanisms of Pharmacological Action