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Exercise in Chronically Paced Children

This study has been completed.
Children's Healthcare of Atlanta
Information provided by (Responsible Party):
Patricio A. Frias, MD, Emory University Identifier:
First received: September 8, 2006
Last updated: May 30, 2012
Last verified: May 2012
The purpose of this study is to evaluate the exercise capacity of patients with complete heart block who are chronically being paced from the right ventricle. Also, we hope to correlate the level of uncoordinated contraction with the patients exercise capacity. We will enroll patients with complete heart block as diagnosed by standard electrocardiographic means and now have a permanent pacemaker. All patients we approach for this study will receive an echocardiogram to assess their heart function. As part of the echocardiogram, they will also receive a Tissue Synchronization Imaging (TSI) evaluation to assess the level of uncoordinated contraction they have. The patients will then be subjected to a cardiac exercise stress test which will involve them running on a treadmill until they cannot continue while data is collected regarding their heart's response to exercise. All portions of the study are noninvasive, which means they work from probes and monitors outside the body.

Congenital Diseases Complete Heart Block Pacemaker

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: A Single Center, Prospective, Pilot Study Examining the Evaluation of Exercise Capacity in Chronically RV Paced Children and Young Adults

Resource links provided by NLM:

Further study details as provided by Patricio A. Frias, MD, Emory University:

Enrollment: 25
Study Start Date: January 2007
Study Completion Date: July 2009
Primary Completion Date: July 2009 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   10 Years to 21 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
pt who have congenital complete heart block with no other preexisting condition that precludes the patient from exercise

Inclusion Criteria:

  • between 10 and 21 years of age
  • structurally normal heart
  • congenital complete heart block
  • dual chamber pacemaker, right ventricular apex paced
  • normal function via traditional transthoracic echocardiography

Exclusion Criteria:

  • preexisting condition that precludes patient from exercise
  • no informed consent
  Contacts and Locations
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Please refer to this study by its identifier: NCT00374608

United States, Georgia
Children's Healthcare of Atlanta - Egleston
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Emory University
Children's Healthcare of Atlanta
Principal Investigator: Patricio A Frias, MD Emory University and Children's Healthcare of Atlanta
  More Information


Responsible Party: Patricio A. Frias, MD, Associate Professor, Pediatrics, Emory University Identifier: NCT00374608     History of Changes
Other Study ID Numbers: 291-2006
Study First Received: September 8, 2006
Last Updated: May 30, 2012

Keywords provided by Patricio A. Frias, MD, Emory University:
congenital complete heart block
dual chamber pacemaker

Additional relevant MeSH terms:
Heart Block
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes processed this record on July 21, 2017