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Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2

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ClinicalTrials.gov Identifier: NCT00374530
Recruitment Status : Completed
First Posted : September 11, 2006
Last Update Posted : August 1, 2007
Sponsor:
Information provided by:
Danish Headache Center

Brief Summary:
Before, during and after intravenous administration of PGE2 we score/measure headache, rCBF, blood flow in the middle cerebral artery and diameter of superficial temporal artery and correlate that to known pathophysiology of headache to see if PGE2 is involved in headache pathophysiology.

Condition or disease Intervention/treatment Phase
Headache Migraine Drug: PGE2 Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Official Title: Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2
Study Start Date : August 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Headache
U.S. FDA Resources




Primary Outcome Measures :
  1. Headache

Secondary Outcome Measures :
  1. rCBF, blood flow, diameter of STA/RA, HR, BP


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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy volunteers

Exclusion Criteria:

  • Primary Headache, headache on the day of the investigation, hypertension, hypotension, pregnant/nursing, daily intake of medication (except oral contraceptives), Cardiovascular or CNS disease, drug/alcohol abuse, psychiatric disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00374530


Locations
Denmark
Danish Headache Center
Glostrup, Denmark, DK-2600
Sponsors and Collaborators
Danish Headache Center
Investigators
Principal Investigator: Troels Wienecke, MD Danish Headache Center

ClinicalTrials.gov Identifier: NCT00374530     History of Changes
Other Study ID Numbers: KA-20060026
First Posted: September 11, 2006    Key Record Dates
Last Update Posted: August 1, 2007
Last Verified: July 2007

Additional relevant MeSH terms:
Headache
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Dinoprostone
Oxytocics
Reproductive Control Agents
Physiological Effects of Drugs