Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2

This study has been completed.

Sponsor:

Information provided by:

Danish Headache Center

ClinicalTrials.gov Identifier:

NCT00374530

First received: September 8, 2006

Last updated: July 31, 2007

Last verified: July 2007

History of Changes

Purpose

Before, during and after intravenous administration of PGE2 we score/measure headache, rCBF, blood flow in the middle cerebral artery and diameter of superficial temporal artery and correlate that to known pathophysiology of headache to see if PGE2 is involved in headache pathophysiology.

Condition	Intervention
Headache Migraine	Drug: PGE2


Study Type:	Interventional
Study Design:	Allocation: Randomized Intervention Model: Crossover Assignment Masking: Double-Blind
Official Title:	Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2

Resource links provided by NLM:

MedlinePlus related topics: Headache

Drug Information available for: Dinoprostone

U.S. FDA Resources

Further study details as provided by Danish Headache Center:

Primary Outcome Measures:

Headache

Secondary Outcome Measures:

rCBF, blood flow, diameter of STA/RA, HR, BP


Estimated Enrollment:	12
Study Start Date:	August 2006

Eligibility


Ages Eligible for Study:	18 Years to 40 Years (Adult)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Healthy volunteers

Exclusion Criteria:

Primary Headache, headache on the day of the investigation, hypertension, hypotension, pregnant/nursing, daily intake of medication (except oral contraceptives), Cardiovascular or CNS disease, drug/alcohol abuse, psychiatric disease

Contacts and Locations

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00374530

Locations


Denmark
Danish Headache Center
Glostrup, Denmark, DK-2600

Sponsors and Collaborators

Danish Headache Center

Investigators


Principal Investigator:	Troels Wienecke, MD	Danish Headache Center

More Information


ClinicalTrials.gov Identifier:	NCT00374530 History of Changes
Other Study ID Numbers:	KA-20060026
Study First Received:	September 8, 2006
Last Updated:	July 31, 2007

Additional relevant MeSH terms:


Headache Pain Neurologic Manifestations Nervous System Diseases Signs and Symptoms	Dinoprostone Oxytocics Reproductive Control Agents Physiological Effects of Drugs

ClinicalTrials.gov processed this record on July 18, 2017

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