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Study of the Relationship Between Blood Vessels and Insulin Response in Adolescents

This study has been completed.
Nationwide Children's Hospital
Information provided by (Responsible Party):
Robert Hoffman, Ohio State University Identifier:
First received: September 7, 2006
Last updated: June 6, 2016
Last verified: June 2016
This study is designed to determine whether there is a relationship between the way insulin and blood vessels work. The difference in the interaction between Caucasian and African American adolescents will also be examined. This may play a role in the differing rates of heart disease and diabetes between the two groups.

Diabetes Mellitus, Type 2
Heart Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Relationship of Endothelial Function to Insulin Sensitivity in African American and Caucasian Adolescents

Resource links provided by NLM:

Further study details as provided by Ohio State University:

Estimated Enrollment: 66
Study Start Date: July 2003
Study Completion Date: June 2006
Primary Completion Date: June 2006 (Final data collection date for primary outcome measure)
Caucasian Adolescents
Caucasian Adolescents
African-American Adolescents
African-American Adolescents

Detailed Description:

Purpose: The purpose of the research is to learn more about how the lining of arteries in the body (called the endothelium) and insulin work in adolescents. Abnormalities in how the blood vessels and insulin work in adolescents may cause high blood pressure, type 2 diabetes, stroke and heart disease.

Healthy adolescents between 8 and 18 years of age are being studied in the Ohio State University General Clinical Research Center. Two visits will be necessary. One will be a screening visit to determine the child's stage of puberty and obtain a medical history. The second will be the study visit. During the latter, blood vessel function will be determined by studying the change in forearm blood flow before and after blood flow to the forearm is stopped. Insulin sensitivity will be determined using glucose water given into a vein.


Ages Eligible for Study:   8 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Inclusion Criteria:

  • Caucasian or African American adolescent
  • Between 8 and 18 years of age

Exclusion Criteria:

  • Pregnancy
  • Chronic Disease
  • Acute Disease
  • Medication Requirement
  Contacts and Locations
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Please refer to this study by its identifier: NCT00374361

United States, Ohio
Ohio State University
Columbus, Ohio, United States, 43210
Sponsors and Collaborators
Ohio State University
Nationwide Children's Hospital
Study Chair: Robert P Hoffman, MD Ohio State University
  More Information

Responsible Party: Robert Hoffman, Professor, Ohio State University Identifier: NCT00374361     History of Changes
Other Study ID Numbers: ENDO 203
AHA 0355195B ( Other Grant/Funding Number: American Heart Association )
Study First Received: September 7, 2006
Last Updated: June 6, 2016
Individual Participant Data  
Plan to Share IPD: No
Plan Description: Observational

Keywords provided by Ohio State University:
insulin sensitivity
endothelial function

Additional relevant MeSH terms:
Diabetes Mellitus
Heart Diseases
Diabetes Mellitus, Type 2
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Cardiovascular Diseases
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on April 25, 2017