Aripiprazole in the Treatment of Patients With Schizophrenia and Symptoms of Obsessive Compulsive Disorder (OCD)
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ClinicalTrials.gov Identifier: NCT00374348 |
Recruitment Status :
Completed
First Posted : September 11, 2006
Last Update Posted : September 16, 2011
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Schizophrenia OCD Obsessive Compulsive Disorder | Drug: Aripiprazole | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 10 participants |
Allocation: | Non-Randomized |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | "Aripiprazole in the Treatment of Patients With Schizophrenia and Symptoms of Obsessive Compulsive Disorder (OCD)". |
Study Start Date : | March 2005 |
Actual Primary Completion Date : | May 2008 |
Actual Study Completion Date : | May 2008 |

- Drug: Aripiprazole
Abilify, 5mg; 10mg; 15mg; 20mg; 30mgOther Name: Abilify
- The overall effectiveness of Aripiprazole will be evaluated by use of the BPRS, Yale-Brown OCD scale and Clinical Global Impression-Improvement (CGI-I) scale, including efficacy in reduction of psychosis and obsessions.Improvements in YBOCS and BPRS scor [ Time Frame: weekly ]
- Physical Examination, Psychiatric evaluation with YBOCS, BPRS and CGI scales, EPS scale, routine hematology and chemistry tests, urinalysis,urine drug screening,urine pregnancy test, ECG recording [ Time Frame: weekly ]

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Man and Women 18-65 years of age.
- Patients who are capable of giving Informed Consent and fluent in English.
- Patients who have DSM IV -Diagnosis of schizophrenia with co-morbid OCD symptoms and BPRS score averaging from mild to moderate (3-4).
- Patients whose obsessive symptoms are not optimally controlled and require a change of treatment.YBOCS score of more than 16.
Exclusion Criteria:
- Outside the age range of 18-65 years.
- Patients with current evidence(past three months) of substance abuse.
- Women of child bearing age who are unwilling to use acceptable methods of contraception.
- Patients who have had recent treatment with long-acting antipsychotic.
- Patients who are suicidal or who have history of recent suicidal attempt.
- History of significant medical condition e.g. seizures, cardiovascular, endocrine,gastrointestinal,renal or respiratory diseases.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00374348
United States, New York | |
Jamaica Hospital Medical Center Department of Psychiatry | |
Jamaica, New York, United States, 11418 |
Principal Investigator: | Isak Isakov, M.D. | Jamaica Hospital Medical Center |
Responsible Party: | Isak Isakov, MD, Department of Psychiatry Research Division |
ClinicalTrials.gov Identifier: | NCT00374348 |
Other Study ID Numbers: |
JH-PSY-Aripiprazole/Schiz/OCD |
First Posted: | September 11, 2006 Key Record Dates |
Last Update Posted: | September 16, 2011 |
Last Verified: | January 2009 |
Schizophrenia with OCD Schizophrenia with-comorbid symptoms of Obsessive Compulsive Disorder(OCD) |
Disease Schizophrenia Compulsive Personality Disorder Obsessive-Compulsive Disorder Pathologic Processes Schizophrenia Spectrum and Other Psychotic Disorders Mental Disorders Personality Disorders Anxiety Disorders Aripiprazole Antidepressive Agents Psychotropic Drugs Antipsychotic Agents Tranquilizing Agents |
Central Nervous System Depressants Physiological Effects of Drugs Dopamine Agonists Dopamine Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Serotonin 5-HT1 Receptor Agonists Serotonin Receptor Agonists Serotonin Agents Serotonin 5-HT2 Receptor Antagonists Serotonin Antagonists Dopamine D2 Receptor Antagonists Dopamine Antagonists |