Comparison Between Marijuana Smoked in Cigarette Paper Versus Cigar Paper
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|ClinicalTrials.gov Identifier: NCT00374127|
Recruitment Status : Completed
First Posted : September 8, 2006
Results First Posted : September 1, 2017
Last Update Posted : September 1, 2017
|Condition or disease||Intervention/treatment||Phase|
|Marijuana Dependence||Drug: Marijuana blunt Drug: marijuana cigarette||Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||35 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Basic Science|
|Official Title:||Comparison Between Marijuana Smoked in Cigarette Paper (Joints) Versus Cigar Paper (Blunts)|
|Study Start Date :||December 2004|
|Actual Primary Completion Date :||August 2008|
|Actual Study Completion Date :||August 2008|
Experimental: marijuana blunt
marijuana blunt (0%, 1.8%, or 3.6% THC)
Drug: Marijuana blunt
Blunts were fabricated by cutting the bottom third off a Dutch Master® cigar, removing all of the cigar tobacco, and replacing it with all of the marijuana contained in a NIDA marijuana cigarette (ca. 800 mg).
Other Name: Blunt
Experimental: marijuana cigarette
marijuana cigarette (0%, 1.8%, or 3.6% THC)
Drug: marijuana cigarette
Marijuana cigarettes were provided by the National Institute on Drug Abuse.
Other Name: Joint
- Plasma THC [ Time Frame: 180 minutes ]Plasma THC levels were analyzed to determine pharmacokinetic differences between marijuana cigarettes vs marijuana blunts.
- Subjective Effects on MRF [ Time Frame: 180 minutes ]Using the Marijuana Rating Form (MRF), subjective effects of "Take Again", "Liking", and "Strong" were assessed. The MRF is a visual analog scale allowing patients to indicate how they feel on a 100-mm line anchored with 'not at all' at the left end and 'extremely' at the right end, when prompted by a statement.
- Subjective Effects on VAS [ Time Frame: 180 minutes ]Subjective VAS ratings of 'Good Drug Effect' and 'High' averaged across all post-smoking time points when marijuana was smoked as joints and blunts analyzed for all participants. Here, participants indicated how they were feeling on a 100-mm line anchored with 'not at all' at the left end and 'extremely' at the right end, when prompted by a statement
- Carbon Monoxide [ Time Frame: 180 minutes ]Expired carbon monoxide averaged across all post-smoking time points when marijuana was smoked as joints and blunts for all participants.
- Heart Rate [ Time Frame: 180 minutes ]Heart rate averaged across all post-smoking time points when marijuana was smoked as joints and blunts.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00374127
|United States, New York|
|New York State Psychiatric Institute|
|New York, New York, United States, 10032|
|Principal Investigator:||Margaret Haney, Ph.D.||New York State Psychiatric Institute|