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Real-Time Support for Exercise Persistence in COPD

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00373932
Recruitment Status : Completed
First Posted : September 8, 2006
Last Update Posted : December 7, 2009
National Institutes of Health (NIH)
Information provided by:
University of Washington

Brief Summary:
The purpose of this exploratory study is to determine the feasibility, acceptability, and efficacy of an exercise persistence intervention for patients with chronic obstructive pulmonary disease (COPD) following pulmonary rehabilitation (PR).

Condition or disease Intervention/treatment Phase
Pulmonary Disease, Chronic Obstructive COPD Emphysema Chronic Bronchitis Behavioral: Coached exercise persistence intervention Behavioral: Self-Monitored exercise persistence intervention Phase 1 Phase 2

Detailed Description:
Exercise, a cornerstone of PR, is effective in improving dyspnea, functioning, and health related quality of life (HRQL) in patients with COPD. However, these improvements gradually dissipate following program completion. There are currently few successful interventions that support patients' persistence with community-based exercise after PR and that have closely monitored the potentially negative impact that COPD exacerbations have on exercise behaviors. Emerging technologies such as wirelessly enabled personal digital assistants (PDA) may provide an innovative means to support exercise persistence through real-time collaborative monitoring of exercise and signs and symptoms of COPD exacerbations and reinforcement to enhance exercise self-efficacy. Patient graduates of two PR programs who have COPD (n=20) will first undergo a 2-week run-in prior to being randomized to either the MOBILE (Mobilizing Support for Long-term Exercise) intervention or attention control for 6 months.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 17 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Official Title: Real-Time Support for Exercise Persistence in COPD
Study Start Date : May 2006
Actual Primary Completion Date : December 2008
Actual Study Completion Date : December 2008

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: MOBILE-A
Coached exercise persistence intervention
Behavioral: Coached exercise persistence intervention
Collaborative symptom and exercise monitoring and weekly reinforcement for exercise persistence from nurse coach via a mobile device and telephone.

Active Comparator: MOBILE-B
Self-monitored exercise persistence intervention
Behavioral: Self-Monitored exercise persistence intervention
Self-monitoring of symptoms and exercise using a mobile device

Primary Outcome Measures :
  1. Exercise behavior [ Time Frame: 3 & 6 Months ]

Secondary Outcome Measures :
  1. Self-efficacy for exercise [ Time Frame: 3 & 6 Months ]
  2. Perception of support [ Time Frame: 3 & 6 Months ]
  3. COPD exacerbation [ Time Frame: 3 & 6 Months ]
  4. Exercise Performance [ Time Frame: 3 & 6 months ]
  5. Health related quality of life [ Time Frame: 3 & 6 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Moderate to severe COPD (FEV1/FVC <70% and FEV1%<80%)
  • Ability to speak, read and write English
  • Age 40 or older
  • Willingness to complete a 6 month program

Exclusion Criteria:

  • Illnesses such as bronchiectasis, active malignancies or other end stage diseases
  • Plans to continue in a maintenance program after rehabilitation.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00373932

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United States, Washington
University of Washington
Seattle, Washington, United States, 98195
Sponsors and Collaborators
University of Washington
National Institutes of Health (NIH)
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Principal Investigator: Huong Q. Nguyen, PhD University of Washington

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Huong Q. Nguyen, PhD, University of Washington Identifier: NCT00373932    
Other Study ID Numbers: 29494-V2
R03NR009361-01A1 ( U.S. NIH Grant/Contract )
First Posted: September 8, 2006    Key Record Dates
Last Update Posted: December 7, 2009
Last Verified: December 2009
Keywords provided by University of Washington:
Physical Activity
Additional relevant MeSH terms:
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Pulmonary Disease, Chronic Obstructive
Bronchitis, Chronic
Lung Diseases
Respiratory Tract Diseases
Pathologic Processes
Lung Diseases, Obstructive
Bronchial Diseases
Respiratory Tract Infections