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Triamcinolone Acetonide in Silicone-Filled Eyes as Adjunctive Treatment for Proliferative Vitreoretinopathy

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ClinicalTrials.gov Identifier: NCT00373282
Recruitment Status : Completed
First Posted : September 8, 2006
Last Update Posted : October 12, 2006
Information provided by:
Shahid Beheshti University of Medical Sciences

Brief Summary:
To evaluate the effect of triamcinolone acetonide in silicone-filled eyes on the outcome of surgery for PVR.

Condition or disease Intervention/treatment Phase
Proliferative Vitreoretinopathy Drug: Triamcinolone acetonide Phase 3

Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Study Start Date : June 2001
Estimated Study Completion Date : June 2003

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Eye Care
U.S. FDA Resources

Primary Outcome Measures :
  1. Single-operation retinal reattachment rate six
  2. months after surgery.

Secondary Outcome Measures :
  1. Visual acuity
  2. Retinal reproliferation
  3. Intraocular pressure
  4. Early silicone oil emulsification

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Cases of rhegmatogenous retinal detachment complicated by PVR grade C undergoing vitrectomy and silicone oil tamponade.

Exclusion Criteria:

  • History of trauma
  • Presence of diabetic retinopathy
  • History of vein occlusion
  • Giant retinal tear

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00373282

Iran, Islamic Republic of
Hamid Ahmadieh,MD
Tehran, Iran, Islamic Republic of, 16666
Sponsors and Collaborators
Shahid Beheshti University of Medical Sciences
Principal Investigator: Hamid Ahmadieh, MD Ophthalmic Research Center of Shaheed Beheshti Medical University

ClinicalTrials.gov Identifier: NCT00373282     History of Changes
Other Study ID Numbers: 8116
First Posted: September 8, 2006    Key Record Dates
Last Update Posted: October 12, 2006
Last Verified: August 2006

Keywords provided by Shahid Beheshti University of Medical Sciences:
Retinal detachment
Silicone oil

Additional relevant MeSH terms:
Vitreoretinopathy, Proliferative
Retinal Diseases
Eye Diseases
Triamcinolone hexacetonide
Triamcinolone Acetonide
Triamcinolone diacetate
Anti-Inflammatory Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Immunosuppressive Agents
Immunologic Factors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action