Procoagulant Effects of Hyperglycemia After Acute Stroke: A Pilot Study
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Procoagulant Effects of Hyperglycemia After Acute Stroke: A Pilot Study|
- FVIIa [ Time Frame: Baseline ] [ Designated as safety issue: No ]FVIIa levels were compared between the normoglycemic and hyperglycemic subjects.
- TF-PCA [ Time Frame: Baseline ] [ Designated as safety issue: No ]TF-PCA levels compared between normoglycemic and hyperglycemic subjects.
|Study Start Date:||October 2001|
|Study Completion Date:||November 2005|
|Primary Completion Date:||November 2005 (Final data collection date for primary outcome measure)|
Subjects with acute stroke, hyperglycemia and history of diabetes.
Subjects with acute stroke and normal blood glucose.
The purpose of this study is to examine the relationships between diabetes mellitus, hyperglycemia,whole blood tissue factor procoagulant activity (TF-PCA) and plasma factorVIIa (FVIIa) in ten patients with type 2 diabetes mellitus and 11 non-diabetic patients at baseline and 6, 12, 24, and 48 hours (h) after presentation for acute stroke.
Patients presenting to the Emergency Department with ongoing stroke symptoms and neurologic deficit less than 24 hours (h) duration were screened for inclusion into the study. Stroke patients were grouped in terms of diabetes status as determined by past medical history. Stroke diagnosis was confirmed with brain magnetic resonance imaging (MRI). Clinical care, including the acute management ofstroke and hyperglycemia, was done at the discretion of the Neurology service not involved in the study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00373269
|Principal Investigator:||Nina T Gentile, MD||Temple University|