To Compare Therapeutic Effect of Intravitreal Bevacizumab and Triamcinolone in Resistant Uveitic Cystoid Macular Edema

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2008 by Shahid Beheshti Medical University.
Recruitment status was  Active, not recruiting
Information provided by:
Shahid Beheshti Medical University Identifier:
First received: August 31, 2006
Last updated: July 28, 2008
Last verified: July 2008
Cystoid macular edema (CME) is one of the common causes of vision loss in patients with UveitiS .Triamcinolone has been effectively used in reducing CME and improving the vision. Also there are some documents which recommend Bevacizumab(avastin) could reduce macular edema. This study compare intravitreous injection of triamcinolone and avastin in patients with resistant uveitic cystoid macular edema.

Condition Intervention Phase
Resistant Cystoid Macular Edema
Drug: Intravitreal injection of Triamcinolone
Drug: Intravitreal injection of Avastin
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Shahid Beheshti Medical University:

Primary Outcome Measures:
  • Resorbed CME in OCT [ Time Frame: every 3 month ] [ Designated as safety issue: No ]
  • Resorbed CME in clinical examination [ Time Frame: Every 3 month ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • need to retreatment [ Time Frame: when ever needed ] [ Designated as safety issue: No ]

Estimated Enrollment: 40
Study Start Date: August 2006
Estimated Study Completion Date: September 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Intravitreal injection of Triamcinolone
Drug: Intravitreal injection of Triamcinolone
4 mg of Triamcinolone
Active Comparator: 2
Intravitreal injection of Avastin
Drug: Intravitreal injection of Avastin
Injection of 1.25 mg of Avastin and

Detailed Description:
This study compare intravitreous injection of triamcinolone and avastin in patients with resistant uveitic cystoid macular edema.

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Uveitic CME
  • Uveitic CME refractory to routine treatment
  • Vision better than 5/200 and worse than 20/50

Exclusion Criteria:

  • Mono- Ocular patients
  • History of vitrectomy
  • Glaucoma or ocular hypertension
  • History of other retinal disease that can cause macular edema
  • Pregnancy
  • Significant media opacity
  • Vision better than 20/50
  Contacts and Locations
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Please refer to this study by its identifier: NCT00371111

Iran, Islamic Republic of
Masoud Soheilian , MD
Tehran, Iran, Islamic Republic of, 16666
Sponsors and Collaborators
Shahid Beheshti Medical University
Principal Investigator: Masoud Soheilian, MD Ophthalmic Research Center of Shaheed Beheshti Medical University
  More Information

No publications provided Identifier: NCT00371111     History of Changes
Other Study ID Numbers: 8524 
Study First Received: August 31, 2006
Last Updated: July 28, 2008
Health Authority: Iran: Ethics Committee

Keywords provided by Shahid Beheshti Medical University:
Resistant uveitic cystoid macular edema
intravitreal triamcinolone
intravitreal bevacizumab

Additional relevant MeSH terms:
Macular Edema
Eye Diseases
Macular Degeneration
Retinal Degeneration
Retinal Diseases
Signs and Symptoms
Triamcinolone Acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Anti-Inflammatory Agents
Enzyme Inhibitors
Hormones, Hormone Substitutes, and Hormone Antagonists
Immunologic Factors
Immunosuppressive Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses processed this record on February 11, 2016