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The Effect of 5-FU and LMW Heparin on the Rate of Retinal Redetachment After Silicone Oil Removal in Cases of PVR

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2007 by Shahid Beheshti University of Medical Sciences.
Recruitment status was:  Active, not recruiting
Information provided by:
Shahid Beheshti University of Medical Sciences Identifier:
First received: August 31, 2006
Last updated: July 11, 2007
Last verified: July 2007
To evaluate the effect of combined 5-FU and low molecular weight heparin in infusion on the rate of retinal redetachment after silicone oil removal in cases of proliferative vitreoretinopathy (PVR).

Condition Intervention Phase
Proliferative Vitreoretinopathy Drug: low molecular weight heparin, 5-FU Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Shahid Beheshti University of Medical Sciences:

Primary Outcome Measures:
  • Retinal redetachment rate

Secondary Outcome Measures:
  • visual acuity
  • intraocular pressure
  • reoperation
  • relative afferent pupillary defect

Study Start Date: February 2005
Estimated Study Completion Date: July 2007

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Cases with history of vitrectomy and silicone oil injection for management of PVR who undergo silicone oil removal

Exclusion Criteria:

  • any sign of retinal redetachment before silicone oil removal
  • any sign of diabetic retinopathy
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Please refer to this study by its identifier: NCT00371020

Iran, Islamic Republic of
Hamid Ahmadieh, MD
Tehran, Iran, Islamic Republic of, 16666
Sponsors and Collaborators
Shahid Beheshti University of Medical Sciences
Principal Investigator: Hamid Ahmadieh, MD Ophthalmic Research Center of Shaheed Beheshti Medical University
  More Information Identifier: NCT00371020     History of Changes
Other Study ID Numbers: 8373
Study First Received: August 31, 2006
Last Updated: July 11, 2007

Keywords provided by Shahid Beheshti University of Medical Sciences:
silicone oil
retinal redetachment
low molecular weight heparin

Additional relevant MeSH terms:
Vitreoretinopathy, Proliferative
Retinal Diseases
Eye Diseases
Calcium heparin
Heparin, Low-Molecular-Weight
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action processed this record on August 16, 2017