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Intravitreal Bevacizumab vs. Bevacizumab Combined With Triamcinolone for Neovascular AMD

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2008 by Shahid Beheshti University of Medical Sciences.
Recruitment status was:  Active, not recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00370370
First Posted: August 31, 2006
Last Update Posted: June 26, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Shahid Beheshti University of Medical Sciences
  Purpose
To compare the efficacy and safety results of intravitreal bevacizumab alone with bevacizumab + triamcinolone acetonide in neovascular AMD.

Condition Intervention Phase
Neovascular Age-Related Macular Degeneration Drug: bevacizumab Drug: bevacizumab + triamcinolone acetonide Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Shahid Beheshti University of Medical Sciences:

Primary Outcome Measures:
  • visual acuity

Secondary Outcome Measures:
  • central macular thickness
  • leakage in fluorescein angiography
  • intraocular pressure
  • anterior chamber reaction

Study Start Date: November 2005
Arms Assigned Interventions
Active Comparator: 1
Injection of intravitreal bevacizumab
Drug: bevacizumab
Injection of intravitreal bevacizumab
Active Comparator: 2
Injection of bevacizumab + triamcinolone acetonide
Drug: bevacizumab + triamcinolone acetonide
Injection of bevacizumab + triamcinolone acetonide

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Cases of active neovascular AMD with visual acuity of 20/400- 20/40

Exclusion Criteria:

  • History of glaucoma or ocular hypertension
  • Disciform scar
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00370370


Locations
Iran, Islamic Republic of
Hamid Ahmadieh, MD
Tehran, Iran, Islamic Republic of, 16666
Sponsors and Collaborators
Shahid Beheshti University of Medical Sciences
Investigators
Principal Investigator: Hamid Ahmadieh, MD Ophthalmic Research Center of Shaheed Beheshti Medical University
  More Information

ClinicalTrials.gov Identifier: NCT00370370     History of Changes
Other Study ID Numbers: 8533
First Submitted: August 30, 2006
First Posted: August 31, 2006
Last Update Posted: June 26, 2008
Last Verified: June 2008

Keywords provided by Shahid Beheshti University of Medical Sciences:
Bevacizumab,
Triamcinolone
Age-related macular degeneration
Choroidal neovascular membrane

Additional relevant MeSH terms:
Macular Degeneration
Wet Macular Degeneration
Retinal Degeneration
Retinal Diseases
Eye Diseases
Bevacizumab
Triamcinolone hexacetonide
Triamcinolone
Triamcinolone Acetonide
Triamcinolone diacetate
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents
Anti-Inflammatory Agents
Glucocorticoids
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Immunosuppressive Agents
Immunologic Factors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action