Transcranial Duplex Scanning and Single Photon Emission Computer Tomography (SPECT) in Parkinsonian Syndromes
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ClinicalTrials.gov Identifier: NCT00368199
: August 24, 2006
Last Update Posted
: February 26, 2018
Maastricht University Medical Center
Funding: Stichting Internationaal Parkinson Fonds, The Netherlands
The purpose of the study is to determine the sensitivity and specificity of transcranial duplex scanning (TCD) and single photon emission computer tomography (SPECT) in patients suspected of having Idiopathic Parkinson Disease (PD) or Atypical Parkinson Syndromes (APS) with as golden standard the clinical diagnosis after 2-year follow-up.
Concordance of hyperechogenic SN with clinical diagnosis of Parkinson's [ Time Frame: 24 months ]
Hyperechogenic substabtia nigra (SN) was assessed at initial visit and after 2 years, patients were re-examined by two movement disorder specialist neurologists for a final clinical diagnosis that served as a surrogate gold standard for our study.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
250 Patients with unclear parkinsonism at the outpatient clinic
Patients with unclear parkinsonism at the outpatient clinic
Known diagnosis at presentation
Life expectation of less than two years because of a non neurological disease