Simvastatin Therapy in Women With Polycystic Ovary Syndrome.
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The purpose of this study is to determine whether statins (simvastatin) improve clinical (excessive hair, skin problems), endocrine (androgens) and metabolic (lipids, markers of systemic inflammation) in women with polycystic ovary syndrome (PCOS).
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Ages Eligible for Study:
18 Years to 40 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
PCO - ESHRE/ASRM criteria: oligomenorrhea (<8 spontaneous menses per year) and hyperandrogenism (hirsutism or acne) or hyperandrogenemia (testosterone >70ng/dl)
Normal prolactin, TSH, 17-OH progesterone
No evidence of androgen producing malignancy, Cushing’s syndrome or acromegaly
Reliable use of birth control pill for at least 3 months and no plans of pregnancy
Elevated creatinine kinase above 2 times upper limit of normal or liver enzymes (transaminases) above 2 times of upper limit of normal
Use of any of the following medications: cyclosporine, fibrates, niacin, antifungal agents, macrolide antibiotics.
Use of oral contraceptives and other steroid hormones 3 months prior to the study