Influence of Physical Training on Mitochondrial Function in Type 2 Diabetic Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00365495
Recruitment Status : Unknown
Verified April 2007 by Odense University Hospital.
Recruitment status was:  Active, not recruiting
First Posted : August 17, 2006
Last Update Posted : April 4, 2007
Information provided by:
Odense University Hospital

Brief Summary:

Physical activity as treatment for patients with type 2 diabetes (T2D). Treatment of T2D is often done by medication, changing the diet and increased physical activity. It is well established that physical training has a positive effect on the pathology of T2D such as increased insulin sensitivity and reduced fasting plasma glucose (7) and blood lipids (15). It is also well known that in healthy subjects endurance training increases mitochondrial density, lipid oxidation during submaximal exercise, and results in a number of qualitative changes in the control of OXPHOS (24). However, the effect of physical training on the mitochondrial function in skeletal muscle of patients with T2D has not been investigated.

The purpose of this project is to investigate the effect of physical training on the mitochondrial respiratory function in muscles of patients with T2D. Skeletal muscle biopsies will be taken before and after 10 weeks of physical training in patients with T2D and matched control subjects. Mitochondria will be isolated from the muscle biopsies, and respiratory function, free radical production and UCP3 will be determined. Furthermore, measures of maximal oxygen consumption (VO2max), heart rate and capillary lactate concentrations and carbohydrate and lipid oxidation will be determined partly to verify an increased aerobic capacity and partly to investigate the changes in these factors in T2D patients.

Condition or disease Intervention/treatment Phase
Type 2 Diabetes Procedure: Physical training (aerobic training) Not Applicable

Study Type : Interventional  (Clinical Trial)
Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single
Primary Purpose: Treatment
Study Start Date : August 2006
Estimated Study Completion Date : June 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Health Checkup

Primary Outcome Measures :
  1. Mitochondrial respiratory measurements. The investigations are carried out by two rounds - one before Christmas and one after.

Secondary Outcome Measures :
  1. VO2max
  2. Lipid oxidation
  3. muscle fiber type composition
  4. muscle oxidative enzymes
  5. mitochondrial-specific proteins (UCP3)
  6. mitochondrial production of free oxygen radicals

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Ages Eligible for Study:   40 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Male,
  • BMI above 26,
  • Age between 40 and 65,
  • Living a sedentary lifestyle

Exclusion Criteria:

  • Women
  • BMI under 26
  • Age under 40 and over 65
  • Trained subjects Control subjects: relatives to type 2 diabetic patients, T2D trial subjects

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00365495

University of Southern Denmark and Odense University Hospital
Odense, Denmark, 5000
Sponsors and Collaborators
Odense University Hospital
Principal Investigator: Martin Mogensen, PhD student University of Southern Denmark Identifier: NCT00365495     History of Changes
Other Study ID Numbers: 022
First Posted: August 17, 2006    Key Record Dates
Last Update Posted: April 4, 2007
Last Verified: April 2007

Keywords provided by Odense University Hospital:
Type 2 diabetes
physical training
mitochondrial function

Additional relevant MeSH terms:
Diabetes Mellitus, Type 2
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases