Original Query: ALL
Previous Study | Return to List | Next Study

Safety and Efficacy of Autologous, Intracoronary Stem Cell Injections in Total Coronary Artery Occlusions

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00365326
Recruitment Status : Completed
First Posted : August 17, 2006
Last Update Posted : March 9, 2011
University Hospitals Cleveland Medical Center
Arteriocyte, Inc.
Information provided by:
Case Western Reserve University

Brief Summary:
This phase I clinical trial will evaluate the safety and efficacy of intra-coronary injection of AC133 selected autologous marrow-derived stem cells in patients with chronic coronary artery occlusion. A clinical study to determine the therapeutic potential of marrow-derived stem cells as an adjunct therapy to current standard therapies for CAD is warranted. The current initiative is to investigate a model of chronic myocardial ischemia and (1) to determine whether intra-coronary injection of selected autologous marrow-derived AC133 stem cells is reasonably safe for use in humans and (2) if this treatment shows any improvement in coronary perfusion, as assessed using non-invasive imaging. This study is structured to evaluate the feasibility and safety of autologous AC133+ bone marrow-derived stem cell via intra-coronary injection into documented ischemic but viable myocardial zones via established collateral vessels. The epicardial vessel that normally supplies the ischemic zone must be 100% chronically occluded and considered non-revascularizable by percutaneous means.

Condition or disease Intervention/treatment Phase
Coronary Occlusion Procedure: catheter-based intracoronary injection Phase 1

Detailed Description:

This study is composed of one phase. The objective of Phase I is to assess the safety and feasibility of performing escalating doses of autologous AC133+ selected bone marrow-derived stem cell with intracoronary infusion via epicardial vessels supplying collateral flow to areas of viable ischemic myocardium in the distribution of a chronic totally occluded vessel. Additionally, focus on the assessment of the benefit achieved from the infusion of stem cells and subsequent angiogenesis at 6 months will be observed.

Potential candidates are patients with a known total occlusion of an epicardial vessel, with a documented chronically ischemic territory supplied by collateral conduits.

Secondary Objectives include:

  1. Improvement in ETT as determined by: total exercise duration on the 6 month ETT in seconds time to: onset of angina, one mm ST depression, onset of angina or one mm ST depression (whichever occurs first)
  2. Reduction in the area of ischemia will be evaluated by nuclear (sestamibi) stress imaging with exercise or pharmacologic stress.
  3. Improvement in viability within the chronically ischemic zone as measured by nuclear (sestamibi) stress imaging.
  4. Improvement in angina as per Angina Questionnaire (The Seattle Angina Questionnaire) at 7, 14, 30, 90, 180, and 365 days.
  5. Major adverse cardiac events (MACE) assessment (composite endpoint including cardiac death, myocardial infarction, ischemia-driven target vessel revascularization, CABG, CVA, and rehospitalization for angina), MACE definitions:

    Myocardial Infarction (All ST segment elevation MIs as diagnosed on electrocardiogram by a staff cardiologist and all non-ST segment elevation MIs as defined by elevation in cardiac enzyme markers per the hospital laboratory guidelines) Cerebral Vascular Accidents (e.g., acute neurological event).

  6. Concomitant Medication usage (e.g., changes in utilization of PRN or sublingual nitroglycerin for angina)
  7. ECG changes at day of discharge, 7, 14, 30, 90, 180, and 365 days.
  8. Functional capacity (e.g., exercise duration (time) and changes in METS achieved on treadmill study at 6 month follow-up).
  9. Echocardiogram assessment of left ventricular ejection fraction and regional wall motion abnormalities at 180 days (e.g., changes in regional wall motion score and/or changes in left ventricular ejection fraction).

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 9 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Safety and Efficacy of Autologous, Intracoronary Stem Cell Injections in Total Coronary Artery Occlusions
Study Start Date : January 2006
Primary Completion Date : June 2007
Study Completion Date : June 2008

Primary Outcome Measures :
  1. Assess the safety and feasibility of performing autologous AC133+ selected bone marrow-derived stem cell intra-coronary infusion and determine whether any benefit is achieved from the infusion of stem cells by non-invasive cardiac assessment.

Secondary Outcome Measures :
  1. Improvement in ETT, reduction in ischemic area, viability improvement (nuclear stress imaging), improvement in angina (Seattle Angina Questionnaire), major adverse cardiac events assessment, echocardiogram assessment of left %EF and regional wall motion.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. The patient must have at least one region of chronically ischemic myocardium formerly perfused by a coronary artery which is now 100% occluded and not revascularizable by conventional percutaneous or surgical methods.
  2. Well-established collateral vessels at least 1.5-mm luminal diameter by coronary angiography to the chronically ischemic myocardium must be identified at the time of diagnostic coronary angiography.
  3. Evidence of viable myocardium in the area supplied by collateral conduits intended for stem cell infusion must be demonstrated by nuclear (sestamibi) stress imaging.
  4. Left ventricular ejection fraction of >45% as per 2D echocardiogram.
  5. Patient must experience class II - IV angina as defined by the Canadian Cardiovascular Society (CCS).
  6. Patient will be followed by the investigating team over the 12 month follow-up period.
  7. The patient must be at least 18 years of age and have signed an informed consent.
  8. If the patient is a female of child-bearing potential, a pregnancy test is negative.

Exclusion Criteria:

Patients meeting any of the following exclusion criteria will be excluded from the study:

  1. Patient with coronary lesions amenable to percutaneous coronary intervention including brachytherapy, or where CABG is indicated.
  2. Any contraindication for cardiac catheterization and percutaneous coronary intervention as per institutional guidelines.
  3. Any contraindication for bone marrow aspiration as per institutional guidelines.
  4. Myocardial infarction within the previous 3 months.
  5. Documented bleeding diathesis.
  6. Known malignancy involving the hematopoietic/lymphoid system.
  7. Patients with baseline ECG abnormalities that would hinder interpretation of baseline ECG uninterpretable for ischemia (e.g., left bundle branch block, left ventricular hypertrophy with strain pattern, Wolff-Parkinson-White syndrome).
  8. Patients with severe co-morbidities including renal failure (serum creatinine > 2.0).
  9. Anticipated unavailability for follow-up visits secondary to psychological or social reasons.
  10. NYHA class III or IV congestive heart failure
  11. Anemia with hemoglobin concentration < 8 mg/dl
  12. Thrombocytopenia with platelet count < 100 x 103

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00365326

United States, Ohio
Case Western Reserve University
Cleveland, Ohio, United States, 44106
Sponsors and Collaborators
Case Western Reserve University
University Hospitals Cleveland Medical Center
Arteriocyte, Inc.
Principal Investigator: Dale Adler, MD Case Western Reserve University
Principal Investigator: Hillard Lazarus, MD Case Western Reserve University

Responsible Party: Ann Charest/Director, Arteriocyte Identifier: NCT00365326     History of Changes
Other Study ID Numbers: HFM-705
First Posted: August 17, 2006    Key Record Dates
Last Update Posted: March 9, 2011
Last Verified: August 2006

Keywords provided by Case Western Reserve University:
bone marrow
coronary artery disease

Additional relevant MeSH terms:
Coronary Occlusion
Coronary Disease
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases