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Molecular Epidemiology of Benzene-exposed Workers.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00364520
Recruitment Status : Completed
First Posted : August 15, 2006
Last Update Posted : May 21, 2015
Sponsor:
Collaborators:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this study is to investigate the health effects of benzene exposure in workers in Shanghai, China.

Condition or disease Intervention/treatment
Hematologic Diseases Other: Shanghai workers

Detailed Description:
The purpose of this study is to investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers and to characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.

Study Design

Study Type : Observational
Actual Enrollment : 2000 participants
Observational Model: Ecologic or Community
Time Perspective: Cross-Sectional
Official Title: Molecular Epidemiology of Benzene-exposed Workers in Shanghai,China
Study Start Date : August 2003
Primary Completion Date : December 2009
Study Completion Date : December 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Blood Disorders
U.S. FDA Resources

Groups and Cohorts

Group/Cohort Intervention/treatment
Shanghai Workers
Shanghai Workers
Other: Shanghai workers


Outcome Measures

Primary Outcome Measures :
  1. Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers. [ Time Frame: August 2003 - December 2009 ]
    Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers


Secondary Outcome Measures :
  1. Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity. [ Time Frame: August 2003 - December 2009 ]
    Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.


Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 67 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Shanghai Workers
Criteria

Inclusion Criteria:

Worked for at least one year in a monitored environment Have at least one physical examination recorded

Exclusion Criteria:

History of cancer, radiation exposure, chemotherapy

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00364520


Locations
China
Joint Sino-US Clinical and Molecular Laboratory (JCML)
Shanghai, China, 200032
Sponsors and Collaborators
University of Colorado, Denver
Fudan University
University of Cincinnati
ExxonMobil Biomedical Sciences, Inc.
British Petroleum P.L.C.
Chevron Corporation
ConocoPhillips
Exxon Mobil
Marathon Ashland
Shell Chemicals
Investigators
Principal Investigator: Richard D Irons, PhD University of Colorado at Denver and Health Sciences Ctr
More Information

Responsible Party: University of Colorado, Denver
ClinicalTrials.gov Identifier: NCT00364520     History of Changes
Other Study ID Numbers: 02-0037
First Posted: August 15, 2006    Key Record Dates
Last Update Posted: May 21, 2015
Last Verified: May 2007

Keywords provided by University of Colorado, Denver:
Hematologic Diseases
Benzene
Genetic Polymorphisms

Additional relevant MeSH terms:
Hematologic Diseases