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Molecular Epidemiology of Benzene-exposed Workers.

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00364520
First Posted: August 15, 2006
Last Update Posted: May 21, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Fudan University
University of Cincinnati
ExxonMobil Biomedical Sciences, Inc.
British Petroleum P.L.C.
Chevron Corporation
ConocoPhillips
Exxon Mobil
Marathon Ashland
Shell Chemicals
Information provided by (Responsible Party):
University of Colorado, Denver
  Purpose
The purpose of this study is to investigate the health effects of benzene exposure in workers in Shanghai, China.

Condition Intervention
Hematologic Diseases Other: Shanghai workers

Study Type: Observational
Study Design: Observational Model: Ecologic or Community
Time Perspective: Cross-Sectional
Official Title: Molecular Epidemiology of Benzene-exposed Workers in Shanghai,China

Resource links provided by NLM:


Further study details as provided by University of Colorado, Denver:

Primary Outcome Measures:
  • Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers. [ Time Frame: August 2003 - December 2009 ]
    Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers


Secondary Outcome Measures:
  • Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity. [ Time Frame: August 2003 - December 2009 ]
    Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.


Enrollment: 2000
Study Start Date: August 2003
Study Completion Date: December 2009
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Shanghai Workers
Shanghai Workers
Other: Shanghai workers

Detailed Description:
The purpose of this study is to investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers and to characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 67 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Shanghai Workers
Criteria

Inclusion Criteria:

Worked for at least one year in a monitored environment Have at least one physical examination recorded

Exclusion Criteria:

History of cancer, radiation exposure, chemotherapy

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00364520


Locations
China
Joint Sino-US Clinical and Molecular Laboratory (JCML)
Shanghai, China, 200032
Sponsors and Collaborators
University of Colorado, Denver
Fudan University
University of Cincinnati
ExxonMobil Biomedical Sciences, Inc.
British Petroleum P.L.C.
Chevron Corporation
ConocoPhillips
Exxon Mobil
Marathon Ashland
Shell Chemicals
Investigators
Principal Investigator: Richard D Irons, PhD University of Colorado at Denver and Health Sciences Ctr
  More Information

Responsible Party: University of Colorado, Denver
ClinicalTrials.gov Identifier: NCT00364520     History of Changes
Other Study ID Numbers: 02-0037
First Submitted: August 14, 2006
First Posted: August 15, 2006
Last Update Posted: May 21, 2015
Last Verified: May 2007

Keywords provided by University of Colorado, Denver:
Hematologic Diseases
Benzene
Genetic Polymorphisms

Additional relevant MeSH terms:
Hematologic Diseases