Effect of GTN and Diamox Measured by BOLD-Response.
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00363792 |
Recruitment Status : Unknown
Verified August 2006 by Danish Headache Center.
Recruitment status was: Recruiting
First Posted : August 15, 2006
Last Update Posted : August 15, 2006
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
In healthy subjects different cerebral haemodynamic values wished to be determined after infusion of the NO donor Glyceryl trinitrate (GTN) and Diamox. The different values we wish to determine are:
- Blood-oxygenation-level-Dependent-signal (BOLD-signal) after visual stimulation.
- Changes in the diameter of a. cerebri media.
- Changes in the regional and global cerebral blodd flow (CBF) with the help of the arterial Spin labeling (ASL) method.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Healthy | Drug: Glyceryl trinitrate, azetazolamide | Not Applicable |
Experimental headache models give a unike opportunity to study pathophysiological mechanisms of prim. headache types such as migraine. Previous studies have used different methods that have had limitations and none of them have had the opportunity to study neuronal activation. But that is possible with the application of functional magnetic resonance (fMRI).
Before we apply fMRI to our experimental headache models it is needed to determine how the BOLD response is influenced and changed by the infusion of different drugs such as the NO donor Glyceryl Trinitrate (GTN) and Diamox (acetazolamide). It is known that GTN causes dilation of the cerebral arteries without having any effect on the regional cerebral blood flow. It is not known what effect GTN has on the BOLD response. Diamox (azetazolamide) increases the CBF but it is uncertain what effect the drug has on the BOLD response. Previous studies disagree gravely on this point.
In this study we will be giving infusion of GTN and Diamox in healty subjects to determine:
- Blood-oxygenation-level-Dependent-signal (BOLD-signal) after visual stimulation.
- Changes in the diameter of a. cerebri media.
- Changes in the regional and global cerebral blodd flow (CBF) with the help of the arterial Spin labeling (ASL) methode.
For the study we will be using a 3-Tesla MRI-scan.
Study Type : | Interventional (Clinical Trial) |
Enrollment : | 12 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Double |
Primary Purpose: | Educational/Counseling/Training |
Official Title: | The Effect of Glyceryl Trinitrate and Diamox on Blood-Oxygenation-Level-Dependent.Signal (BOLD-Signal) and Cerebral Haemodynamics With the Use of a 3-Tesla MRI-Scan. |
Study Completion Date : | May 2007 |
- Changes in BOLD response
- Changes in a. cerebri media diameter
- Changes in CBF
- headache score

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years to 55 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- healthy subjects
- age 18-55 years
- weight 50-100 kg
Exclusion Criteria:
- Tension type headache more the once per month.
- other types of headache
- Daily use of medication other the birthcontrol pills.
- Pregnant or lactating women.
- headache on the examination date.
- contraindications to MRI-scan.
- hypotension or hypertension.
- mental illness og substance abuse.
- other significant conditions determined by the examining doctor.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00363792
Contact: Mohammad Sohail Asghar, MD | +4543232161 | asgsoh01@glostruphosp.kbhamt.dk |
Denmark | |
Danish Headache Center | Recruiting |
Glostrup, Denmark, 2770 | |
Contact: Mohammad Sohail Asghar, MD +4543232161 asgsoh01@glostruphosp.kbhamt.dk | |
Principal Investigator: Mohammad Sohail Asghar, MD |
Study Chair: | Messoud Ashina, MD, Phd, | Danish Headache Center |
ClinicalTrials.gov Identifier: | NCT00363792 |
Other Study ID Numbers: |
KA-20060085 |
First Posted: | August 15, 2006 Key Record Dates |
Last Update Posted: | August 15, 2006 |
Last Verified: | August 2006 |
Healthy subjects |
Nitroglycerin Vasodilator Agents |