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Pilot Study of Continuing Aspirin Versus Switching to Clopidogrel After Stroke or Transient Ischemic Attack

This study has been withdrawn prior to enrollment.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00363753
First Posted: August 15, 2006
Last Update Posted: April 2, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of California, San Diego
  Purpose
Pilot study of continuing aspirin versus switching to clopidogrel after stroke or transient ischemic attack.

Condition Intervention Phase
Transient Ischemic Attack Stroke Aspirin Clopidogrel Drug: aspirin versus clopidogrel Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Pilot Study of Continuing Aspirin Versus Switching to Clopidogrel After Stroke or Transient Ischemic Attack

Resource links provided by NLM:


Further study details as provided by University of California, San Diego:

Primary Outcome Measures:
  • mRS at three months.

Secondary Outcome Measures:
  • Incidence of stroke at three months, bleeding events.

Estimated Enrollment: 20
Study Start Date: August 2006
Estimated Study Completion Date: March 2007
Detailed Description:
Pilot study of continuing aspirin versus switching to clopidogrel after stroke or transient ischemic attack.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Age 18 and older.
  • Stroke or transient ischemic attack (TIA) while taking aspirin within one week of consent.
  • Women of child-bearing potential will be included only if there is a negative pregnancy test and they agree to birth control during the treatment period.

Exclusion Criteria:

  • Any medical indication for a specific antiplatelet agent (aspirin, clopidogrel, ticlopidine, aggrenox), or an indication for a combination of antiplatelet agents.
  • Any medical indication for anticoagulation, except subcutaneous heparin for deep vein thrombosis prophylaxis.
  • Allergy to aspirin or clopidogrel.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00363753


Locations
United States, California
UCSD Hillcrest
San Diego, California, United States, 92103
UCSD
San Diego, California, United States, 92103
Sponsors and Collaborators
University of California, San Diego
Investigators
Principal Investigator: Matt B Jensen, MD UCSD Stroke Center
  More Information

ClinicalTrials.gov Identifier: NCT00363753     History of Changes
Other Study ID Numbers: UCSD IRB #060452
First Submitted: August 10, 2006
First Posted: August 15, 2006
Last Update Posted: April 2, 2007
Last Verified: March 2007

Keywords provided by University of California, San Diego:
Transient ischemic attack
Stroke
Aspirin
Clopidogrel

Additional relevant MeSH terms:
Ischemia
Ischemic Attack, Transient
Brain Ischemia
Stroke
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Pathologic Processes
Aspirin
Ticlopidine
Clopidogrel
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action
Platelet Aggregation Inhibitors
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Antipyretics
Purinergic P2Y Receptor Antagonists