The Effect of Glyceryl Trinitate and Diamox on Cerebral Haemodynamics.

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.

Verified July 2006 by Danish Headache Center.
Recruitment status was: Not yet recruiting

Sponsor:

Information provided by:

Danish Headache Center

ClinicalTrials.gov Identifier:

NCT00363571

First received: August 14, 2006

Last updated: NA

Last verified: July 2006

History: No changes posted

Purpose

After infusion / injection of Glyceryl trinitrate and Diamox it is wished to study the effect of drugs on the cerebral haemodynamics such as Cerebral blod flow and cerebral blod volume.

Condition	Intervention
Migraine	Drug: GTN, Diamox


Study Type:	Interventional
Study Design:	Allocation: Randomized Intervention Model: Crossover Assignment Masking: Double-Blind Primary Purpose: Educational/Counseling/Training
Official Title:	The Effect of Glyceryl Trinitrate (GTN) and Diamox on Cerebral Haemodynamics Judged With the Help of 3-Tesla MRI.

Resource links provided by NLM:

Drug Information available for: Acetazolamide Acetazolamide sodium

U.S. FDA Resources

Further study details as provided by Danish Headache Center:


Estimated Enrollment:	12
Study Start Date:	August 2006
Estimated Study Completion Date:	May 2007

Detailed Description:

Experimental headache model open a unike opportunity to study the pathophysiological mechanisms behind headache in general and migrane in particular. Previous studies have used various techniques to study the cerebral haemodynamics as a basis for the headache pathophysiology. We wish to use a 3-Tesa MRI so study the cerebral haemodynamics after application of various pharmacological substances.

The most used experimental headache model is the glyceryl trinitrate model (GTN). Where infusion of the NO donor GTN induces headache and changes in the cerebral arteries. On the other hand injection of Diamox (Acetazolamide) apparently causes increase of the cerebral blod flow with out dilation of the arteries. We wish to study the precise effect of GTN and diamox on the cerebral haemodynamics such as Cerebral blod flow (CBF) and Cerebral blod volume (CBV) via a 3-Tesla MRI.

Eligibility


Ages Eligible for Study:	18 Years to 55 Years (Adult)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

healthy volunteers; men and women age 18-50 years.
weight 50-100 kg

Exclusion Criteria:

Tension type headache more then once per month during the last year.
Other primary headache types.
Daily use of medication.
Pregnant or lactating women.
Headache on the trail day or 24 hours prior to the trial.
Contraindications to MRI.
Hypotension og hypertension.
Other significant medical conditions judged by the doctor in charge.

Contacts and Locations

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00363571

Contacts


Contact: Mohammad Sohail Asghar, MD	+4543232161	asgsoh01@glostruphosp.kbhamt.dk

Locations


Denmark
Danish Headache Center, Neurological Dep. Glostrup hospital
Glostrup, Denmark, 2770

Sponsors and Collaborators

Danish Headache Center

Investigators


Study Chair:	Messoud Ashina, MD,Ph.D	Danish Headache Center

More Information


ClinicalTrials.gov Identifier:	NCT00363571 History of Changes
Other Study ID Numbers:	KA-20060084
Study First Received:	August 14, 2006
Last Updated:	August 14, 2006

Additional relevant MeSH terms:


Acetazolamide Anticonvulsants Carbonic Anhydrase Inhibitors Enzyme Inhibitors	Molecular Mechanisms of Pharmacological Action Diuretics Natriuretic Agents Physiological Effects of Drugs

ClinicalTrials.gov processed this record on July 18, 2017

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