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The Effect of Glyceryl Trinitate and Diamox on Cerebral Haemodynamics.

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2006 by Danish Headache Center.
Recruitment status was:  Not yet recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00363571
First Posted: August 15, 2006
Last Update Posted: August 15, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Danish Headache Center
  Purpose
After infusion / injection of Glyceryl trinitrate and Diamox it is wished to study the effect of drugs on the cerebral haemodynamics such as Cerebral blod flow and cerebral blod volume.

Condition Intervention
Migraine Drug: GTN, Diamox

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Educational/Counseling/Training
Official Title: The Effect of Glyceryl Trinitrate (GTN) and Diamox on Cerebral Haemodynamics Judged With the Help of 3-Tesla MRI.

Resource links provided by NLM:


Further study details as provided by Danish Headache Center:

Estimated Enrollment: 12
Study Start Date: August 2006
Estimated Study Completion Date: May 2007
Detailed Description:

Experimental headache model open a unike opportunity to study the pathophysiological mechanisms behind headache in general and migrane in particular. Previous studies have used various techniques to study the cerebral haemodynamics as a basis for the headache pathophysiology. We wish to use a 3-Tesa MRI so study the cerebral haemodynamics after application of various pharmacological substances.

The most used experimental headache model is the glyceryl trinitrate model (GTN). Where infusion of the NO donor GTN induces headache and changes in the cerebral arteries. On the other hand injection of Diamox (Acetazolamide) apparently causes increase of the cerebral blod flow with out dilation of the arteries. We wish to study the precise effect of GTN and diamox on the cerebral haemodynamics such as Cerebral blod flow (CBF) and Cerebral blod volume (CBV) via a 3-Tesla MRI.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy volunteers; men and women age 18-50 years.
  • weight 50-100 kg

Exclusion Criteria:

  • Tension type headache more then once per month during the last year.
  • Other primary headache types.
  • Daily use of medication.
  • Pregnant or lactating women.
  • Headache on the trail day or 24 hours prior to the trial.
  • Contraindications to MRI.
  • Hypotension og hypertension.
  • Other significant medical conditions judged by the doctor in charge.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00363571


Contacts
Contact: Mohammad Sohail Asghar, MD +4543232161 asgsoh01@glostruphosp.kbhamt.dk

Locations
Denmark
Danish Headache Center, Neurological Dep. Glostrup hospital
Glostrup, Denmark, 2770
Sponsors and Collaborators
Danish Headache Center
Investigators
Study Chair: Messoud Ashina, MD,Ph.D Danish Headache Center
  More Information

ClinicalTrials.gov Identifier: NCT00363571     History of Changes
Other Study ID Numbers: KA-20060084
First Submitted: August 14, 2006
First Posted: August 15, 2006
Last Update Posted: August 15, 2006
Last Verified: July 2006

Additional relevant MeSH terms:
Acetazolamide
Anticonvulsants
Carbonic Anhydrase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Diuretics
Natriuretic Agents
Physiological Effects of Drugs