Functional MRI (fMRI) in CGRP Induced Migraine
In patients known with migraine without aura a migraine headache or migraine like headache will be induced by infusion of calcitonin gene related peptide (CGRP). The patients will then be stimulated with noxious heat via a thermode placed at the forehead. At the same time the Blood-oxygenation-level-dependent (BOLD) response will be measured via functional magnetic resonance imaging (fMRI), to estimate the central-nervous pain response. The regions of interest (ROI) will be thalamic region and medulla oblongata.
Then the patients will be given pain relif in form of injection of sumatriptan and the effect of this will also be registered via measuring the BOLD response at the RIO's previously defined. A 3-Tesla MRI scanner will be used in this trail.
This study will give us key knowledge of the trigeminal pain pathway and the central processing i.e sensitization during a migraine attach.
|Migraine Without Aura||Drug: infusion of calcitonin gene related peptide (CGRP)|
|Study Design:||Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single Blind
Primary Purpose: Treatment
|Official Title:||Functional MRI (fMRI) in Patients With Migraine Without Aura Provoked by|
- Changes in BOLD response before and after CGRP infusion.
- Changes in BOLD response before and after injection of sumatriptan.
|Study Start Date:||September 2006|
|Study Completion Date:||July 2007|
|Primary Completion Date:||July 2007 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00363532
|Danish Headache Center, Neurological Dep. Glostrup hospital|
|Glostrup, Denmark, 2770|
|Study Chair:||Messoud Ashina, MD,PH.d||Danish Headache Center|