The Potential Effects and Mechanisms of Flax Lignans on Type 2 Diabetes Mellitus
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The purpose of the study is to improving the lipid profile and glucose control in type 2 diabetic patients with supplementation of flax lignans. We hypothesize that flax lignans supplement will improve the cholesterol profile and glucose control in type 2 diabetic patients.
Condition or disease
Type 2 DiabetesHypercholesterolemia
Drug: flax lignans
Phase 2Phase 3
The prevalence of type 2 diabetes is increasing dramatically in the last decade in China. Hyperlipidemia is a comorbid condition in type 2 diabetes and increase the adverse health outcomes. Flax lignans, a phytoestrogen found in flaxseed is thought to be the compound responsible for cholesterol-lowering effect of flaxseed. Our purpose is to improving the lipid profile in type 2 diabetic patients with supplementation of flax lignans.
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Ages Eligible for Study:
50 Years to 79 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Diagnosed type 2 diabetes
Age: 50-79 years old
LDL-cholesterol more than 2.9 mmol/l
Current or previous (within 6 months) use of estrogen therapy
Chronic gastrointestinal diseases
Current use of antibiotics
Any severe liver or renal diseases
Systolic blood pressure more than 180 mmHg or phase 3 hypertension