Community - Associated Extended-spectrum Beta-lactamases (ESBL)
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|ClinicalTrials.gov Identifier: NCT00363220|
Recruitment Status : Completed
First Posted : August 15, 2006
Last Update Posted : December 17, 2015
The purpose of this study is to review patients with E. coli infections at the University of Pittsburgh Medical Center (UPMC) from September 1, 2006 to August 31, 2007 to determine if these infections have arisen in the community rather than in hospitals or nursing homes. The occurrence of such resistant isolates could be devastating if they were associated with bloodstream infection, such as sometimes accompanies a urinary tract infection, since antibiotic resistant E. coli is not suspected in isolates coming from the community. Therefore, the aims of this study are to:
- Review whether extended-spectrum beta-lactamase (ESBL)-producing organisms (E. coli, Klebsiella species and Proteus species) are hospital-acquired, healthcare-associated, or community-associated.
- Investigate the prevalence of ESBL-positive E. coli in foodstuffs (beef, poultry, turkey, and pork), as a potential source for ESBL producers in the community.
- Compare the clonal relationship of the genome and resistance plasmids carried by the ESBL-producing isolates (healthcare-associated, community-associated, and of animal origin) and study the associations of ESBL-mediated resistance with resistance to other classes of antimicrobials.
|Condition or disease|
|Infection E Coli Infections Klebsiella Infections Proteus Infections|
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||Community - Associated Extended-spectrum Beta-lactamases (ESBL)|
|Study Start Date :||August 2006|
|Actual Primary Completion Date :||December 2015|
|Actual Study Completion Date :||December 2015|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00363220
|United States, Pennsylvania|
|University of Pittsburgh Medical Center|
|Pittsburgh, Pennsylvania, United States, 15213|
|Principal Investigator:||Yohei Doi, MD||University of Pittsburgh|