Alemtuzumab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV T-Cell Non-Hodgkin's Lymphoma
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|ClinicalTrials.gov Identifier: NCT00363090|
Recruitment Status : Unknown
Verified June 2009 by National Cancer Institute (NCI).
Recruitment status was: Recruiting
First Posted : August 15, 2006
Last Update Posted : September 20, 2013
RATIONALE: Monoclonal antibodies, such as alemtuzumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, vincristine, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from growing. Giving alemtuzumab together with combination chemotherapy may kill more cancer cells.
PURPOSE: This phase I/II trial is studying the side effects and best dose of alemtuzumab when given together with combination chemotherapy and to see how well they work in treating patients with newly diagnosed aggressive stage II, stage III, or stage IV T-cell non-Hodgkin's lymphoma.
|Condition or disease||Intervention/treatment||Phase|
|Lymphoma||Biological: alemtuzumab Drug: cyclophosphamide Drug: doxorubicin hydrochloride Drug: prednisone Drug: vincristine sulfate Other: flow cytometry Other: pharmacological study||Phase 1 Phase 2|
- Establish the safety and dose-limiting toxicities of alemtuzumab in combination with cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (CHOP) chemotherapy in patients with newly diagnosed, stage II-IV aggressive peripheral T-cell non-Hodgkin's lymphoma.
- Measure the pharmacokinetics of alemtuzumab using different subcutaneous doses and schedules to determine the dose with the highest achievable drug levels with acceptable toxicities worthy of further investigation.
- Determine the efficacy of alemtuzumab in combination with CHOP chemotherapy using escalating doses and 2 different drug schedules, as defined by overall response rate, progression-free survival, and overall survival.
- Measure the effects of this regimen on T-cell reconstitution and cytomegalovirus reactivation.
OUTLINE: This is a multicenter, phase I, dose-escalation study of alemtuzumab followed by an open-label, phase II study.
- Phase I: Patients receive CHOP chemotherapy comprising cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine IV on day 1 and oral prednisone on days 1-5. Patients also receive alemtuzumab subcutaneously (SC) on day 1 OR on days 1, 8, and 15. Treatment repeats every 3 weeks for up to 8 courses in the absence of disease progression or unacceptable toxicity.
Cohorts of 3-6 patients receive escalating doses of alemtuzumab until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.
- Phase II: Patients receive CHOP chemotherapy and alemtuzumab (at the MTD determined in phase I) as in phase I (on the most effective regimen).
Patients undergo blood collection at baseline, periodically during study treatment, and after completion of study treatment for pharmacokinetics and other correlative studies. Samples are examined for presence of cytomegalovirus antigen and by flow cytometry for B- and T-cell quantification.
After completion of study treatment, patients are followed periodically.
PROJECTED ACCRUAL: A total of 84 patients will be accrued for this study.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||84 participants|
|Masking:||None (Open Label)|
|Official Title:||Alemtuzumab and CHOP Chemotherapy for Aggressive Histology Peripheral T Cell Lymphomas: A Multi-Centre Phase I and II Study|
|Study Start Date :||September 2006|
|Estimated Primary Completion Date :||December 2010|
- Toxicity as assessed by NCI Common Toxicity Criteria Version 3.0
- Dose-limiting toxicities
- Pharmacokinetics of alemtuzumab
- Efficacy as assessed by clinical, radiologic, pathologic, and laboratory measurements
- Overall response rate
- Progression-free survival
- Overall survival
- Effects of treatment on T- and B-cell reconstitution by flow cytometry at baseline and at 3, 6, and 12 months
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00363090
|Canada, British Columbia|
|St. Paul's Hospital at Providence Health Care - Vancouver||Recruiting|
|Vancouver, British Columbia, Canada, V6Z 1Y6|
|Contact: Contact Person 604-806-9656|
|Margaret and Charles Juravinski Cancer Centre||Recruiting|
|Hamilton, Ontario, Canada, N6A 4L6|
|Contact: Graeme Fraser, MD, FRCPC 905-575-7820|
|London Regional Cancer Program at London Health Sciences Centre||Recruiting|
|London, Ontario, Canada, N6A 4L6|
|Contact: Joy Mangel, MD 519-685-8615 firstname.lastname@example.org|
|Odette Cancer Centre at Sunnybrook||Recruiting|
|Toronto, Ontario, Canada, M4N 3M5|
|Contact: Rena Buckstein, MD 416-480-5847 email@example.com|
|Princess Margaret Hospital||Recruiting|
|Toronto, Ontario, Canada, M5G 2M9|
|Contact: Michael R. Crump, MD, FRCPC 416-946-4567 firstname.lastname@example.org|
|Study Chair:||Rena Buckstein, MD||Toronto Sunnybrook Regional Cancer Centre|