Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure
This is a comparative study performed in 3 groups of patients/subjects: 30 severe sepsis patients, 30 non-septic patients with organ failure, 30 healthy subjects.
The only intervention is a venous blood sampling at the onset of the disease.
The purpose of the study is to compare the PC pathway and expression and inflammatory genes between the 3 groups. The main hypothesis is that systemic inflammatory response and exacerbated coagulation activation are non specific of an infection as a triggering event.
|Severe Sepsis Organ Failure|
|Study Design:||Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
|Official Title:||Comparative Study of the Protein C Pathway in Septic and Non Septic Patients|
|Study Start Date:||March 2003|
|Estimated Study Completion Date:||October 2003|
analysis of the PC pathway
- PC activity
- PS activity
- soluble thrombomodulin
- soluble EPCR
- activated protein C
- quantitative flow cytometry on monocytes (thrombomodulin and EPCR)
- whole blood mRNA (Tissue factor, thrombomodulin and EPCR)
- inflammatory gene expression analysis by MLPA
Please refer to this study by its ClinicalTrials.gov identifier: NCT00361725
|Principal Investigator:||Jean-Luc DIEHL, MD||Assistance Publique - Hôpitaux de Paris|