Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure
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|ClinicalTrials.gov Identifier: NCT00361725|
Recruitment Status : Terminated
First Posted : August 8, 2006
Last Update Posted : August 15, 2006
This is a comparative study performed in 3 groups of patients/subjects: 30 severe sepsis patients, 30 non-septic patients with organ failure, 30 healthy subjects.
The only intervention is a venous blood sampling at the onset of the disease.
The purpose of the study is to compare the PC pathway and expression and inflammatory genes between the 3 groups. The main hypothesis is that systemic inflammatory response and exacerbated coagulation activation are non specific of an infection as a triggering event.
|Condition or disease|
|Severe Sepsis Organ Failure|
analysis of the PC pathway
- PC activity
- PS activity
- soluble thrombomodulin
- soluble EPCR
- activated protein C
- quantitative flow cytometry on monocytes (thrombomodulin and EPCR)
- whole blood mRNA (Tissue factor, thrombomodulin and EPCR)
- inflammatory gene expression analysis by MLPA
|Study Type :||Observational|
|Enrollment :||90 participants|
|Observational Model:||Case Control|
|Observational Model:||Natural History|
|Official Title:||Comparative Study of the Protein C Pathway in Septic and Non Septic Patients|
|Study Start Date :||March 2003|
|Study Completion Date :||October 2003|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00361725
|Principal Investigator:||Jean-Luc DIEHL, MD||Assistance Publique - Hôpitaux de Paris|