An Open Label Treatment Extension Study of AMG 706
This is an extension study to provide ongoing treatment with AMG 706 monotherapy for subjects with solid tumors who have completed the planned duration of AMG 706 treatment on a separate Amgen protocol and have been evaluated as having stable disease or better. Subjects who are no longer eligible to continue AMG 706 treatment on a separate Amgen protocol (for reasons other than AMG 706 intolerance), but who are receiving clinical benefit or have the potential to receive clinical benefit from AMG 706 per the investigator are also eligible to participate in this trial.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||An Open Label Treatment Extension Study of AMG 706|
- Safety (serious adverse events, adverse events, blood pressure and laboratory tests) [ Time Frame: Until objective evidence of disease progression, AMG 706 intolerance, or until loss of clinical benefit ] [ Designated as safety issue: No ]
|Study Start Date:||December 2005|
|Study Completion Date:||July 2012|
|Primary Completion Date:||July 2012 (Final data collection date for primary outcome measure)|
There are no arms to this study
Drug: AMG 706
The dose of AMG 706 will be administered at the same dose level and schedule received at the conclusion of the previous study but will be no greater than 125 mg QD or 75 mg BID.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00360867