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Study of Optimal Treatment Plan in Hypertensives With Anti-AT1-Receptor Autoantibody

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2006 by Huazhong University of Science and Technology.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00360763
First Posted: August 7, 2006
Last Update Posted: August 7, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Huazhong University of Science and Technology
  Purpose
The autoantibodies against AT1 receptor (ATR-AA), behaving like an agonist were detected in patients with hypertension. ATR-AA which can blocked by ARB may play a role in the pathogenesis of hypertension. The present study is to explore whether AT1 receptor blocker has superior anti-hypertensive effect in patients with positive ATR-AA hypertension. Patients with 2 grade hypertension were recruited and ATR-AA was assayed by ELISA. A study was carried out and the efficacy of anti-hypertension was compared between candesartan cilexetil and ACE inhibitor imidapril.

Condition Intervention Phase
Hypertension Drug: candesartan cilexetil Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Huazhong University of Science and Technology:

Estimated Enrollment: 600
Estimated Study Completion Date: December 2006
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Hypertension (2 grade)

Exclusion Criteria:

  • Secondary hypertension
  • Known sensitivity or intolerance to an angiotensin II receptor antagonist or ACE inhibitor
  • Pregnancy
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00360763


Locations
China, Hubei
Department of Cardiology, Wuhan Union Hospital Recruiting
Wuhan, Hubei, China, 430022
Contact: Yu-Hua Liao, Doctor    00862785726376    yumiaowei@vip.sina.com   
Sponsors and Collaborators
Huazhong University of Science and Technology
Investigators
Study Director: Yu-Hua Liao Union Hospital, Tongji Medical College
  More Information

Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00360763     History of Changes
Other Study ID Numbers: UH-01
First Submitted: August 4, 2006
First Posted: August 7, 2006
Last Update Posted: August 7, 2006
Last Verified: August 2006

Additional relevant MeSH terms:
Candesartan
Candesartan cilexetil
Antihypertensive Agents
Angiotensin II Type 1 Receptor Blockers
Angiotensin Receptor Antagonists
Molecular Mechanisms of Pharmacological Action