Study of Optimal Treatment Plan in Hypertensives With Anti-AT1-Receptor Autoantibody
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ClinicalTrials.gov Identifier: NCT00360763
Verified August 2006 by Huazhong University of Science and Technology. Recruitment status was: Recruiting
The autoantibodies against AT1 receptor (ATR-AA), behaving like an agonist were detected in patients with hypertension. ATR-AA which can blocked by ARB may play a role in the pathogenesis of hypertension. The present study is to explore whether AT1 receptor blocker has superior anti-hypertensive effect in patients with positive ATR-AA hypertension. Patients with 2 grade hypertension were recruited and ATR-AA was assayed by ELISA. A study was carried out and the efficacy of anti-hypertension was compared between candesartan cilexetil and ACE inhibitor imidapril.
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Ages Eligible for Study:
18 Years to 80 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Hypertension (2 grade)
Known sensitivity or intolerance to an angiotensin II receptor antagonist or ACE inhibitor