Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers

This study has been completed.
Information provided by:
Medical University of Vienna
ClinicalTrials.gov Identifier:
First received: August 2, 2006
Last updated: December 10, 2007
Last verified: December 2007
The aim of this study is to determine if oxytocin administration is able to blunt LPS induced increase of cytokines (TNF-α) and if there is a change in the endocrine response after lipopolysaccharide administration in humans.

Condition Intervention
Drug: oxytocin

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers

Resource links provided by NLM:

Further study details as provided by Medical University of Vienna:

Primary Outcome Measures:
  • TNF-alpha [ Time Frame: six hours ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • ACTH, cortisol, procalcitonin, IL-1ra, IL-4, IL-6, MIP-1alpha, MIP-1 beta, MCP-1, IP-10, VEGF, body temperature, BNP, Ghrelin, [ Time Frame: six hours ] [ Designated as safety issue: No ]

Estimated Enrollment: 10
Study Start Date: August 2006

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Men aged 18 years or older with no disease history
  • Written informed consent

Exclusion Criteria:

  • Receiving any medication
  • Probands who suffer from infectious disease
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00360048

Medical University of Vienna
Vienna, Austria, 1090
Sponsors and Collaborators
Medical University of Vienna
Principal Investigator: Martin Clodi, MD, Associate Professor Medical University of Vienna
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00360048     History of Changes
Other Study ID Numbers: 2006-000246-39  EK-Nr.: 014/2006 
Study First Received: August 2, 2006
Last Updated: December 10, 2007
Health Authority: Austria: Federal Ministry for Health and Women

Keywords provided by Medical University of Vienna:

Additional relevant MeSH terms:
Pharmacologic Actions
Physiological Effects of Drugs
Reproductive Control Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on May 01, 2016