Comparison of Two Different Medications Used to Treat Elevated Intracranial Pressure
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ClinicalTrials.gov Identifier: NCT00359697
Verified November 2014 by Thomas Jefferson University. Recruitment status was: Not yet recruiting
The overall purpose of this study is to compare the effects of mannitol and hypertonic saline on patients with increased intracranial pressure. The hypothesis being tested is that hypertonic saline is more effective in controlling increased intracranial pressure than mannitol.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Documented SAH (by computed tomography or lumbar puncture), ICH, TBI or brain tumor
Patient greater than or equal to 18 years of age
ICP monitor in place
ICP greater than 20mmHg, not related to a transient noxious stimulus and not responding to standard measures for controlling ICP (ventricular drainage, elevation of head of the bed and optimizing PaCO2)
Patient or patient's legally authorized representative has provided written informed consent
Patient less than 18 years of age
Lack of ICP monitoring
Patient received Mannitol prior to placement of ICP monitor
Baseline serum osmolarity of greater than 310 mOsm/L
Patient is currently enrolled in another investigational drug or device study