Influenza Vaccination of Nursing Home Workers.
The objective of this study is to demonstrate that influenza vaccination of nursing home workers is an effective intervention for reducing mortality of elderly people.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||VAXICOL: Effectiveness of Influenza Vaccination of Nursing Home Workers on Mortality of Nursing Home Residents. A Cluster Randomized Trial.|
- all-cause mortality of residents at one year
- hospitalizations of residents,morbidity of nursing home workers.
- A cost-effectiveness ratio of influenza vaccination will be calculated
|Study Start Date:||September 2006|
|Estimated Study Completion Date:||October 2007|
Nursing homes will be randomized within each pair in two arms “incentive to vaccinate”, and “do-nothing”. In the arm “incentive to vaccinate”, vaccination campaigns will be carried out with face-to-face interviews of nursing home workers in order to achieve more than 80% of vaccination coverage. In the “do-nothing”, nursing home workers will be vaccinated as usual.
The main endpoint criterion is all-cause mortality of residents. Population sets will be all residents who will be present at start of the influenza season (-2 weeks) or who will be admitted during the influenza season (+ 2 weeks). Onset and end of influenza season will be given by regional influenza surveillance system. Secondary criteria are hospitalizations of residents, morbidity of nursing home workers. A cost-effectiveness ratio of influenza vaccination will be calculated.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00359554
|Hopital Saint Antoine Inserm U707|
|Paris, France, 75012|
|Principal Investigator:||Fabrice CARRAT, MD,||Assistance Publique - Hôpitaux de Paris|