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The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

This study has been completed.
Information provided by:
University of Alabama at Birmingham Identifier:
First received: July 28, 2006
Last updated: February 16, 2010
Last verified: February 2010
To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.

Acute Renal Failure Chronic Kidney Failure Endothelial Dysfunction Hemolytic-uremic Syndrome (HUS)

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

Resource links provided by NLM:

Further study details as provided by University of Alabama at Birmingham:

Enrollment: 36
Study Start Date: April 2008
Study Completion Date: July 2009
Primary Completion Date: July 2009 (Final data collection date for primary outcome measure)
those with previous history of Acute kidney injury

Detailed Description:
This research study is designed to study what happens to the kidneys after they have an injury. There is some evidence that even if there appears to be great improvement of kidney function, an injury can put patients at risk for long-term problems with their kidney function and increase their risk to have high blood pressure. We want to collect information from participants to help explain why this injury can cause future problems, including Chronic Kidney Disease (CKD) which may help us prevent these health problems.

Ages Eligible for Study:   2 Years to 20 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Children 2-20 years old with history of acute kidney injury

Inclusion Criteria:

  • Children between age 2-20
  • Decrease in renal function by 25% or greater
  • Renal function has returned to normal

Exclusion Criteria:

  • History of chronic disease
  • Cancer
  • Congenital heart disease
  • Organ Transplantation
  • Liver disease
  • Pulmonary disease
  • Diabetes other primary metabolic condition
  • Severe neurologic impairments
  • Hypertension
  • Auto-immune
  • Infectious disease or renal disease
  • Smokers
  • Renal disease w/primary cause i.e. - HUS or Glomerulonephritis
  • severe allergies including allergy to seafood and/or iodine
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00358306

Sponsors and Collaborators
University of Alabama at Birmingham
Principal Investigator: David Askenazi, MD UAB Pediatric Nephrology
  More Information

Responsible Party: David Askenazi M.D., UAB Identifier: NCT00358306     History of Changes
Other Study ID Numbers: F070309010
Study First Received: July 28, 2006
Last Updated: February 16, 2010

Keywords provided by University of Alabama at Birmingham:
Chronic Kidney Disease
Acute Kidney Injury
Hemolytic-uremic syndrome (HUS)

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Renal Insufficiency
Acute Kidney Injury
Kidney Failure, Chronic
Hemolytic-Uremic Syndrome
Urologic Diseases
Pathologic Processes
Anemia, Hemolytic
Hematologic Diseases
Thrombotic Microangiopathies
Blood Platelet Disorders processed this record on September 19, 2017