We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00358306
First Posted: July 31, 2006
Last Update Posted: February 17, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Alabama at Birmingham
  Purpose
To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.

Condition
Acute Renal Failure Chronic Kidney Failure Endothelial Dysfunction Hemolytic-uremic Syndrome (HUS)

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

Resource links provided by NLM:


Further study details as provided by University of Alabama at Birmingham:

Enrollment: 36
Study Start Date: April 2008
Study Completion Date: July 2009
Primary Completion Date: July 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts
a
those with previous history of Acute kidney injury

Detailed Description:
This research study is designed to study what happens to the kidneys after they have an injury. There is some evidence that even if there appears to be great improvement of kidney function, an injury can put patients at risk for long-term problems with their kidney function and increase their risk to have high blood pressure. We want to collect information from participants to help explain why this injury can cause future problems, including Chronic Kidney Disease (CKD) which may help us prevent these health problems.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   2 Years to 20 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Children 2-20 years old with history of acute kidney injury
Criteria

Inclusion Criteria:

  • Children between age 2-20
  • Decrease in renal function by 25% or greater
  • Renal function has returned to normal

Exclusion Criteria:

  • History of chronic disease
  • Cancer
  • Congenital heart disease
  • Organ Transplantation
  • Liver disease
  • Pulmonary disease
  • Diabetes other primary metabolic condition
  • Severe neurologic impairments
  • Hypertension
  • Auto-immune
  • Infectious disease or renal disease
  • Smokers
  • Renal disease w/primary cause i.e. - HUS or Glomerulonephritis
  • severe allergies including allergy to seafood and/or iodine
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00358306


Sponsors and Collaborators
University of Alabama at Birmingham
Investigators
Principal Investigator: David Askenazi, MD UAB Pediatric Nephrology
  More Information

Responsible Party: David Askenazi M.D., UAB
ClinicalTrials.gov Identifier: NCT00358306     History of Changes
Other Study ID Numbers: F070309010
First Submitted: July 28, 2006
First Posted: July 31, 2006
Last Update Posted: February 17, 2010
Last Verified: February 2010

Keywords provided by University of Alabama at Birmingham:
Endothelium
Chronic Kidney Disease
Acute Kidney Injury
Hemolytic-uremic syndrome (HUS)

Additional relevant MeSH terms:
Hemolytic-Uremic Syndrome
Kidney Diseases
Renal Insufficiency, Chronic
Renal Insufficiency
Acute Kidney Injury
Hemolysis
Kidney Failure, Chronic
Urologic Diseases
Pathologic Processes
Uremia
Anemia, Hemolytic
Anemia
Hematologic Diseases
Thrombotic Microangiopathies
Thrombocytopenia
Blood Platelet Disorders