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Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00357864
First Posted: July 28, 2006
Last Update Posted: August 30, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Danish Headache Center
  Purpose
To investigate headache score and accompanying symptoms during and after infusion of carbachol.

Condition Intervention
Headache Drug: carbachol

Study Type: Observational
Study Design: Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Basic Research on Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow in a Humane Experimental Headache Model

Resource links provided by NLM:


Further study details as provided by Danish Headache Center:

Enrollment: 15
Study Start Date: July 2006
Study Completion Date: April 2007
Detailed Description:

To investigate headache score and accompanying symptoms during and after infusion of carbachol.

Changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), blood flow in MCA, diameter of the superficial temporal artery (STA) and radial artery (RA)

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy volunteers
  • Aged 18-40
  • 50-100 kg
  • Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion Criteria:

  • Tension type headache more than once/month
  • Other primary headaches
  • Daily medication except contraceptives
  • Drug taken within 4 times the halflife for the specific drug except contraceptives
  • Pregnant or lactating women
  • Exposure to radiation within the last year
  • Headache within the last 24 hours before start of trial
  • Hypertension
  • Hypotension
  • Respiratory or cardiac disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00357864


Locations
Denmark
Dansih Headache Center
Glostrup, Denmark, 2600
Sponsors and Collaborators
Danish Headache Center
Investigators
Principal Investigator: henrik schytz Danish Headache Center
  More Information

ClinicalTrials.gov Identifier: NCT00357864     History of Changes
Other Study ID Numbers: 2006-002462-19
First Submitted: July 26, 2006
First Posted: July 28, 2006
Last Update Posted: August 30, 2007
Last Verified: August 2007

Additional relevant MeSH terms:
Headache
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Carbachol
Cardiotonic Agents
Miotics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Protective Agents