Safety and Effects of Ramipril Combined With Candesartan
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we hypothesized that combination therapy has additive beneficial effects to improve endothelial dysfunction and adipocytokine profiles in patients with hypertension.
Condition or disease
Drug: ramipril, candesartan
Forty patients will be given ramipril 10 mg and placebo, ramipril 10 mg and candesartan 16 mg, or candesartan 16 mg and placebo daily in a randomized, double-blind, placebo-controlled cross-over trial with three treatment arms and two washout periods (each 2 months).
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Ages Eligible for Study:
35 Years to 75 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
patients with mild to moderate hypertension
We will exclude patients with severe hypertension, unstable angina, acute myocardial infarction, or renal insufficiency.