Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.
Recruitment status was: Enrolling by invitation
|Movement Disorders Parkinson Disease Parkinsonian Disorders Dystonia Tourette Syndrome||Procedure: Sedation with IV propofol|
|Study Design:||Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Changes of the Neuronal Activity in the Subthalamic Nucleus Under Propofol Sedation During Stereotactic Electrode Implantation.|
- Changes in the electrical activity of neuron cells of the basal ganglia in the examined patients [ Time Frame: Within 24 hours needed to analyse the data ]
|Study Start Date:||September 2006|
|Estimated Study Completion Date:||July 2008|
Procedure: Sedation with IV propofol
Deep Brain Stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who have to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the Basal Ganglia.
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to propofol sedation. Electrical activity of single neurons will be recorded before and after sedation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00355927
|Hadassah Medical Organization|
|Jerusalem, Israel, 91120|
|Principal Investigator:||Dan Eimerl, MD||Hadassah Medical Organization|
|Principal Investigator:||Zvi Israel, MD||Hadassah Medical Organization|