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Coronary Atherosclerosis Evaluation by Arterial Wall Magnetic Resonance Imaging (MRI)

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ClinicalTrials.gov Identifier: NCT00353795
Recruitment Status : Completed
First Posted : July 19, 2006
Results First Posted : June 22, 2010
Last Update Posted : June 22, 2010
Northwestern University
Information provided by:
Johns Hopkins University

Brief Summary:

The overall goal of this study is to use MRI to:

  • Examine the relationship between known risk factors for cardiovascular disease and coronary artery wall thickness;
  • Examine the relationship between coronary artery wall thickness and other markers of subclinical coronary atherosclerosis, such as carotid wall thickness and coronary calcium scores; and,
  • Examine the feasibility of measuring the progression of coronary artery wall thickness over time in a subset of participants.

Condition or disease Intervention/treatment
Coronary Arteriosclerosis Arteriosclerosis, Coronary Atherosclerosis, Coronary Coronary Artery Disease Coronary Atherosclerosis Procedure: MR Imaging of the Coronary Arteries

Detailed Description:
Each enrolled participant will undergo MR Imaging of the coronary arteries in conjunction with their routine MESA follow-up visit. The MRI will last approximately 45-60 minutes

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 179 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Coronary Atherosclerosis Evaluation by Arterial Wall MRI
Study Start Date : July 2005
Primary Completion Date : June 2008
Study Completion Date : June 2008

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Primary Outcome Measures :
  1. Mean Coronary Wall Thickness [ Time Frame: n/a (cross sectional analysis) ]
    Average thickness of the wall of the left anterior descending, right and left main coronary artery measured by magnetic resonance imaging (MRI).

Information from the National Library of Medicine

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Ages Eligible for Study:   45 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Prior enrollment in the MESA Study at the Hopkins MESA Field Center or the Northwestern University MESA Field Center
  • Male or Female adult equal to or older than 45 years of age
  • Willing/able to provide informed consent

Exclusion Criteria:

  • Any known contraindications to MRI (i.e. severe claustrophobia, pacemaker, etc.)
  • Metal in the eyes

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00353795

United States, Illinois
Northwestern University MESA Field Center
Chicago, Illinois, United States, 60611
United States, Maryland
Johns Hopkins MESA Field Center
Baltimore, Maryland, United States, 21244
Sponsors and Collaborators
Johns Hopkins University
Northwestern University
Principal Investigator: David A Bluemke, MD PhD Johns Hopkins University

Additional Information:
ClinicalTrials.gov Identifier: NCT00353795     History of Changes
Other Study ID Numbers: 05-05-23-01
5R01HL078909 ( U.S. NIH Grant/Contract )
First Posted: July 19, 2006    Key Record Dates
Results First Posted: June 22, 2010
Last Update Posted: June 22, 2010
Last Verified: September 2009

Keywords provided by Johns Hopkins University:

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases