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Transcranial Doppler Measurement and Prognosis in Moderate Head Injury

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00353444
Recruitment Status : Suspended (Technical Conflicts)
First Posted : July 18, 2006
Last Update Posted : November 6, 2008
Information provided by:
Universidad Autonoma de San Luis Potosí

Brief Summary:
The purpose of this study is to determine whether Transcranial Doppler measurements have correlation with neuropsychological test (Galvestone Orientation Amnesia Test), TC image (Marshall Scale) and prognosis (DRS and GOS) in moderate head injury

Condition or disease
Head Injury

Detailed Description:

The head injury is a frequent problem of health, which produces high morbi-mortality. Today is the main cause of death and disability between 18 and 40 years. In addition it originates expensive expenses in health care systems.

Severity of cerebral injury is not only because of impact, it is implicated many physiopathological changes. Decrease or increase of cerebral blood flow (CBF) play important roll formation of edema and intracranial hypertension. Hypoxic/ischemic damage is the final point of both changes.

The transcranial Doppler (TCD) was introduced around 1982. Through TCD can be measured the flow velocity of intracranial arteries, which let us identify changes in diameter in vessels. There are three windows of access to arteries: transtemporal, transorbitary and suboccipital.

The parameter are systolic velocity (S), tele-diastolic velocity (D), mean velocity (M) and pulsatility index (PI). Many studies have been conducted for evaluate utility in head injury, TCD can identify changes that correlate with alteration in CBF intracranial pressure (ICP).

The autoregulatory status is important, TCD with decrement in D and increment in PI could tell us about failure in this issue. An invasive way for estimate cerebral perfusion pressure (CCP) with TCD. The most sensible for fall in is amplitude in FV. However there is more correlation between CPP and PI. Vasospasm can occur post trauma, for identify the Lindegaard ratio (FVcma/FVcia) is useful. The other change, hyperemia, can be demonstrated by continuously increase FV. In post traumatic time is very important identify alterations which could produce ischemia. The measurement of CPP generally is gotten by invasión with ICP determination.

In severe head injury has been demonstrated correlation between ICP and PI, strongest for CPP and PI. Other parameters are oligaemia and vasospasm in the first 24 hours correlate poor outcome.

Because of the non invasive characteristic and good correlation with physiologic and prognosis, we think it is important evaluate if there are a kind of correlation between amnesia and orientation, prognosis and TCD parameters.

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Study Type : Observational
Enrollment : 70 participants
Time Perspective: Prospective
Official Title: Transcranial Doppler Measurement and Prognosis in Moderate Head Injury
Study Start Date : December 2006
Study Completion Date : March 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Head Injuries

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 50 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Man or woman >16 and <50 years with HI less 24 hours in progression and Glasgow between 9 y 12.
  2. Man or woman >16 and <50 years with HI and Glasgow l3, with lesions in TC scan.
  3. TC scan.
  4. Acceptance of family to participate (first grade).

Exclusion Criteria:

  1. History of HI with disability
  2. History of neurological or psychiatric disease with disability.
  3. Existence of systemic injury with life in compromise (massive bleeding, exposition in fracture, hepatic or splenic laceration or in great vessels and shock).
  4. Existence of intracranial lesion which needs surgery.
  5. Cerebral death certificated by neurologist or neurosurgeon (EEG o arteriography).
  6. Management previous in other Hospital.
  7. Hemoglobin < 10 g/L

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00353444

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Hospital Central "Dr. Ignacio Morones Prieto"
San Luis Potosi, Mexico, 78240
Sponsors and Collaborators
Universidad Autonoma de San Luis Potosí
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Principal Investigator: Torres-Corzo Jaime, Neurosurgeon Hospital Central "Dr. Ignacio Morones Prieto"
Principal Investigator: Tapia-Perez Humberto, MD Facultad de Medicina UASLP
Layout table for additonal information Identifier: NCT00353444    
Other Study ID Numbers: 27-07TCDHI
First Posted: July 18, 2006    Key Record Dates
Last Update Posted: November 6, 2008
Last Verified: November 2008
Keywords provided by Universidad Autonoma de San Luis Potosí:
head injury
transcranial Doppler
pulsatility index
vasospasm in head injury
Additional relevant MeSH terms:
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Craniocerebral Trauma
Wounds and Injuries
Trauma, Nervous System
Nervous System Diseases