Lung Tumour Volume Database
The main aim is to determine, in patients with locoregional, non-small cell lung cancer (NSCLC) treated by definitive radiotherapy, the influence on survival of the volume of primary tumour, as measured from CT imaging, after adjusting for the effect of the current TNM staging system and other known prognostic factors (especially ECOG performance and weight loss).
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Tumour Volume as an Independent Prognostic Factor in Patients With Non-Small Cell Lung Cancer - A Protocol for a Prospective Database.|
- Survival [ Time Frame: End of Study ] [ Designated as safety issue: No ]Survival duration defined as the time from date of registration until death from any cause
|Study Start Date:||September 1999|
|Study Completion Date:||November 2012|
|Primary Completion Date:||February 2009 (Final data collection date for primary outcome measure)|
Patients with loco-regional, NSCLC treated by definitive radiotherapy.
Radiation: Definitive Radiotherapy
60Gy in 6 weeks, 50Gy in 4 weeks. Each individual fraction should not exceed 2.5Gy.
Other Name: Radiation
Patients with locoregional non small cell lung cancer are registered on study after tumour volumes are outlined by a radiologist and prior to the commencement of any treatment.
All patients must have recorded the volume of disease in the primary tumour (and of involved nodes > 1 cm diameter) as measured from a CT scan performed according to a standard set of conditions.
Following registration patients are treated with Definitive radiotherapy with or without chemotherapy. Follow-up will occur with the collection of a minimum amount of data every 12 months from the date of registration on study.
Quality Assurance procedures will be implemented with each site that participates in the study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00351598
|Australia, New South Wales|
|St George Hospital|
|Kogarah, New South Wales, Australia, 2217|
|Liverpool, New South Wales, Australia, 1871|
|Newcastle Mater Misericordiae Hospital|
|Newcastle, New South Wales, Australia, 2298|
|Royal Prince Alfred Hospital|
|Sydney, New South Wales, Australia, 2050|
|Wentworthville, New South Wales, Australia, 2145|
|South Brisbane, Queensland, Australia, 4101|
|East Coast Cancer Centre|
|Tugun, Queensland, Australia, 4224|
|Princess Alexandra Hospital|
|Woolloongabba, Queensland, Australia, 4102|
|Australia, South Australia|
|Royal Adelaide Hospital|
|Adelaide, South Australia, Australia, 5000|
|Peter MacCallum Cancer Centre|
|East Melbourne, Victoria, Australia, 3002|
|Heidelberg, Victoria, Australia, 3081|
|Prahran, Victoria, Australia, 3181|
|Australia, Western Australia|
|Sir Charles Gairdner Hospital|
|Nedlands, Western Australia, Australia, 6009|
|Auckland, New Zealand, 1001|
|National University Hospital|
|Study Chair:||David Ball||Peter MacCallum Cancer Centre, Australia|