Failure of Implantation After Recurrent Embryo Transfers

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00351481
Recruitment Status : Completed
First Posted : July 13, 2006
Last Update Posted : May 29, 2008
Information provided by:
UMC Utrecht

Brief Summary:
We will investigate maternal and embryonic factors in women with recurrent implantation failure, undergoing IVF/ ICSI treatment. Women who have not achieved a pregnancy after three embryo transfer procedures will undergo an endometrial biopsy during the window of implantation in a natural cycle. During the next treatment cycle we will aspirate endometrial secretion and perform a doppler ultrasound investigation of the a. uterina. Moreover, we will investigate the cytokine expression from the transferred embryo from the culture medium.

Condition or disease

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 80 participants
Official Title: Recurrent Embryo Implantation Failure in Women Undergoing IVF/ ICSI; an Investigation of the Intra-Uterine Environment During the Window of Implantation
Study Start Date : July 2006
Actual Primary Completion Date : May 2008
Actual Study Completion Date : May 2008

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 37 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Women who have not achieved a pregnancy, despite 3 subsequent embryo transfers, of which only one is allowed to be a transfer of a cryo-thawed embryo. A chemical pregnancy or E.U.G. will not be regarded as a pregnancy. An abortion will be regarded as a pregnancy.

Exclusion Criteria:

  • women older than 37 years.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00351481

University Medical Center Utrecht
Utrecht, Netherlands, 3584CX
Sponsors and Collaborators
UMC Utrecht
Study Chair: Nick Macklon, Professor UMC Utrecht

Publications: Identifier: NCT00351481     History of Changes
Other Study ID Numbers: FIRE-study
First Posted: July 13, 2006    Key Record Dates
Last Update Posted: May 29, 2008
Last Verified: April 2007

Keywords provided by UMC Utrecht:
endometrial receptivity
embryo implantation
recurrent implantation failure

Additional relevant MeSH terms:
Genital Diseases, Male
Genital Diseases, Female