We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Attention and Visual Perception in Schizophrenia: A Functional Magnetic Resonance Imaging (fMRI) Study

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00350935
First Posted: July 11, 2006
Last Update Posted: June 28, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Institut National de la Santé Et de la Recherche Médicale, France
Centre National de la Recherche Scientifique, France
Région Alsace
Faculté de Médecine de Strasbourg
Information provided by:
University Hospital, Strasbourg, France
  Purpose
The main objective of the study is to contribute to a better understanding of the physiopathology of schizophrenia, by studying causal relationships between cognitive deficits and the neurobiological basis for these deficits. Processing visual information involves both automatic grouping processes and control processes. Automatic grouping processes allow the building of a global configuration from local contour information. It is necessary in order to recognize objects. Control processes allow tending to and prioritizing information parts. The paradigm the investigators use allows to dissociate these processes, and is used in order to characterize the impairments observed in patients with schizophrenia. It is adapted to fMRI in order to explore the neurobiological basis of the deficits. The investigators will examine whether functional disconnectivity between activated areas subtend the impairments observed in patients.

Condition Intervention
Schizophrenia Procedure: fMRI

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Attention and Grouping of Visual Information: What is Disturbed in Patients With Schizophrenia?

Resource links provided by NLM:


Further study details as provided by University Hospital, Strasbourg, France:

Estimated Enrollment: 52
Study Start Date: September 2006
Study Completion Date: April 2009
Groups/Cohorts Assigned Interventions
Healthy volunteers
Healthy controls
Procedure: fMRI
One 30 minute session
Patients
Patients with schizophrenia
Procedure: fMRI
One 30 minute session

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Primary care clinic, residents of Strasbourg
Criteria

Inclusion Criteria:

  • Patients with schizophrenia (DSM-IV criteria)
  • Healthy controls matched with patients on age, sex and education level
  • Ages 18 to 50
  • Signed informed consent
  • Right-handed

Exclusion Criteria:

  • No severe somatic illness
  • No invalidating sensory disease
  • No drug abuse, as defined by DSM-IV criteria
  • No general anaesthesia in the past 3 months
  • No intake of drugs affecting the CNS, except for patients
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00350935


Locations
France
Inserm U666 - Département de Psychiatrie, Hôpitaux Universitaires de Strasbourg
Strasbourg, France, 67091
Sponsors and Collaborators
University Hospital, Strasbourg, France
Institut National de la Santé Et de la Recherche Médicale, France
Centre National de la Recherche Scientifique, France
Région Alsace
Faculté de Médecine de Strasbourg
Investigators
Principal Investigator: Anne Giersch, MD Institut National de la Santé Et de la Recherche Médicale, France
  More Information

Responsible Party: Emmanuel LAVOUE, Directeur Adjoint de la DRCI, University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT00350935     History of Changes
Other Study ID Numbers: 3456
First Submitted: July 10, 2006
First Posted: July 11, 2006
Last Update Posted: June 28, 2010
Last Verified: June 2010

Keywords provided by University Hospital, Strasbourg, France:
fMRI
Visual perception
Attention

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders