Hydroxyurea for Children and Young Adults With Sickle Cell Disease and Pulmonary Hypertension
Sickle Cell Disease
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||A Pilot Study of Hydroxyurea for the Treatment of Pulmonary Hypertension in Children and Young Adults With Sickle Cell Disease|
- Tricuspid Regurgitant Jet Velocity [ Time Frame: 6 and 12 months after HU therapy begins ] [ Designated as safety issue: No ]Primary outcome measure was tricuspid regurgitant jet velocity (TRJV) by echocardiogram after 6 and 12 months of hydroxyurea therapy.
- Compliance [ Time Frame: Throughout study ] [ Designated as safety issue: No ]Secondary outcome measures included compliance; laboratory measures of therapy-related toxicity; laboratory biomarkers for hemolysis, oxidative stress and endothelial injury; and quality of life measures by Child Health Questionnaire (CHQ).
|Study Start Date:||July 2006|
|Study Completion Date:||June 2008|
|Primary Completion Date:||June 2008 (Final data collection date for primary outcome measure)|
20 mg/kg/day and dose escalating every 2 months until maximum tolerated dose.
Increasing evidence suggests that pulmonary hypertension, defined by an elevated tricuspid regurgitant jet velocity (TRJV) on echocardiogram, is a major cause of morbidity and mortality in adults with sickle cell disease (SCD). However, both the prevalence and optimal treatment of pulmonary hypertension in children and young adults with SCD are unknown.
We hypothesize that short term therapy with hydroxyurea will decrease TRJV in children and young adults with pulmonary hypertension found on screening. Patients eligible for treatment will have had evidence of pulmonary hypertension on at least 2 screening echocardiograms. Baseline laboratory tests will be obtained and other causes of secondary pulmonary hypertension will be excluded prior to initiation of treatment. Patients will be treated with hydroxyurea according to a standard dose escalation schedule for a total of 12 months. A clinic visit will be required every 2 months and standard screening for toxicity will be performed monthly. There will be an interim analysis of the primary outcome at 6 months following therapy.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00350844
|United States, Illinois|
|Children's Memorial Hospital|
|Chicago, Illinois, United States, 60614-3394|
|Principal Investigator:||Robert I Liem, MD||Ann & Robert H Lurie Children's Hospital of Chicago|