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Measuring Time Windows in Patients With Schizophrenia and Healthy Controls

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00350805
First Posted: July 11, 2006
Last Update Posted: October 5, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Institut National de la Santé Et de la Recherche Médicale, France
Centre National de la Recherche Scientifique, France
Institut de Physique Biologique de Strasbourg
Information provided by (Responsible Party):
University Hospital, Strasbourg, France
  Purpose
Abnormalities in the ability to distinguish events in time may have a great impact on everyday life. The main objective of the study is to evaluate the magnitude of the temporal windows in schizophrenia, i.e. the time interval during which two events are perceived as synchronous. The investigators test the hypothesis that these temporal windows are enlarged, and check the relationship between this impairment and disorganization symptoms, in order to explore the link between this cognitive impairment and clinical symptoms. They explore also the neurobiological bases of the impairment by means of electroencephalogram (EEG) recordings. Event-related potentials (N50) will reveal whether or not the coding of the stimuli has the same temporal characteristics in patients and controls. The distribution and amplitude of oscillatory activities will be analyzed as a function of the synchronous or asynchronous response of the subject, thus allowing to explore the links between synchrony perception and neuronal synchronization phenomena.

Condition Intervention
Schizophrenia Procedure: EEG

Study Type: Observational
Study Design: Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Relating the 'Experienced Present' With the Mechanisms of Neuronal Function: A Comparative Study in Patients With Schizophrenia and Healthy Controls Using Psychophysical and Neurophysiological Methods

Resource links provided by NLM:


Further study details as provided by University Hospital, Strasbourg, France:

Enrollment: 126
Actual Study Start Date: September 2005
Study Completion Date: December 2012
Primary Completion Date: April 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Healthy volunteers Procedure: EEG
One 20 minutes session
Patients Procedure: EEG
One 20 minutes session

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Primary care clinic, residents of Strasbourg
Criteria

Inclusion Criteria:

  • Patients with schizophrenia (DSM-IV criteria)
  • Healthy controls matched with patients on age, sex and education level
  • Age between 18 and 50
  • Informed consent signed
  • No severe somatic illness
  • No invalidating sensory disease
  • No drug abuse, as defined by DSM-IV criteria
  • No general anesthesia in the past 3 months
  • No intake of drug affecting the CNS, except for patients
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00350805


Locations
France
Service de Psychiatrie Adulte & INSERM U841, Hôpital Albert Chenevier et Henri Mondor (AP-HP)
Créteil, France, 94000
Centre Hospitalier de Rouffach
Rouffach, France, 68250
INSERM U666 - Département de Psychiatrie - Hôpitaux Universitaires de Strasbourg
Strasbourg, France, 67091
Sponsors and Collaborators
University Hospital, Strasbourg, France
Institut National de la Santé Et de la Recherche Médicale, France
Centre National de la Recherche Scientifique, France
Institut de Physique Biologique de Strasbourg
Investigators
Principal Investigator: Anne GIERSCH, MD Institut National de la Santé Et de la Recherche Médicale, France
  More Information

Responsible Party: University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT00350805     History of Changes
Other Study ID Numbers: 3494
First Submitted: July 10, 2006
First Posted: July 11, 2006
Last Update Posted: October 5, 2017
Last Verified: September 2017

Keywords provided by University Hospital, Strasbourg, France:
Schizophrenia
Time perception
Cortical synchronization
Electroencephalography

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders