Measuring Time Windows in Patients With Schizophrenia and Healthy Controls
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00350805
: July 11, 2006
Last Update Posted
: October 5, 2017
University Hospital, Strasbourg, France
Institut National de la Santé Et de la Recherche Médicale, France
Centre National de la Recherche Scientifique, France
Abnormalities in the ability to distinguish events in time may have a great impact on everyday life. The main objective of the study is to evaluate the magnitude of the temporal windows in schizophrenia, i.e. the time interval during which two events are perceived as synchronous. The investigators test the hypothesis that these temporal windows are enlarged, and check the relationship between this impairment and disorganization symptoms, in order to explore the link between this cognitive impairment and clinical symptoms. They explore also the neurobiological bases of the impairment by means of electroencephalogram (EEG) recordings. Event-related potentials (N50) will reveal whether or not the coding of the stimuli has the same temporal characteristics in patients and controls. The distribution and amplitude of oscillatory activities will be analyzed as a function of the synchronous or asynchronous response of the subject, thus allowing to explore the links between synchrony perception and neuronal synchronization phenomena.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:
18 Years to 50 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Primary care clinic, residents of Strasbourg
Patients with schizophrenia (DSM-IV criteria)
Healthy controls matched with patients on age, sex and education level
Age between 18 and 50
Informed consent signed
No severe somatic illness
No invalidating sensory disease
No drug abuse, as defined by DSM-IV criteria
No general anesthesia in the past 3 months
No intake of drug affecting the CNS, except for patients