Laser Iridotomy Versus Phacoemulsification in Acute Angle Closure
This is a randomised controlled clinical trial to compare laser peripheral iridotomy (LPI) and primary phacoemulsification with intra-ocular lens implantation (phaco/IOL) in the treatment of acute primary angle-closure glaucoma (APACG). Following successful medical lowering of raised intra-ocular pressure (IOP) and control of intraocular inflammation, patients presenting to Singapore National Eye Centre and Singapore General Hospital with acute primary angle-closure glaucoma who meet the eligibility are randomised to one of the two treatment arms: laser peripheral iridotomy and primary phacoemulsification with intra-ocular lens implantation. These patients will be monitored closely for 2 years post-operatively.
Angle Closure Glaucoma
Procedure: Laser Preipheral Iridotomy and phacoemulsification
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Angle Closure: Laser Iridotomy Versus Phacoemulsification Study (ACLIPS)- A Study of Acute Primary Angle Closure Glaucoma Comparing Two Treatment Modalities: Laser Peripheral vs Phacoemulsification With Posterior Intraocular Lens Implant|
- Recurrence of APACG: Patients who develop a recurrence of symptoms of APACG. Treatment of recurrence will be decided by the ophthalmologist managing the patient.
- IOP lowering medication is required.
- Further glaucoma surgery is required.
- Cataract surgery is required. Patients in the LPI group who develop significant progression of cataract during the follow-up period will be offered cataract extraction.
- No light perception
- Eyes become phthisical
|Study Start Date:||October 2001|
|Estimated Study Completion Date:||October 2007|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00350428
|Singapore National Eye Centre|
|Singapore, Singapore, 168751|
|Principal Investigator:||Steve Seah, FRCS (Ed)||Singapore National Eye Centre|