Laser Iridotomy Versus Phacoemulsification in Acute Angle Closure
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This is a randomised controlled clinical trial to compare laser peripheral iridotomy (LPI) and primary phacoemulsification with intra-ocular lens implantation (phaco/IOL) in the treatment of acute primary angle-closure glaucoma (APACG). Following successful medical lowering of raised intra-ocular pressure (IOP) and control of intraocular inflammation, patients presenting to Singapore National Eye Centre and Singapore General Hospital with acute primary angle-closure glaucoma who meet the eligibility are randomised to one of the two treatment arms: laser peripheral iridotomy and primary phacoemulsification with intra-ocular lens implantation. These patients will be monitored closely for 2 years post-operatively.
Condition or disease
Angle Closure Glaucoma
Procedure: Laser Preipheral Iridotomy and phacoemulsification
Angle Closure: Laser Iridotomy Versus Phacoemulsification Study (ACLIPS)- A Study of Acute Primary Angle Closure Glaucoma Comparing Two Treatment Modalities: Laser Peripheral vs Phacoemulsification With Posterior Intraocular Lens Implant
Study Start Date
Estimated Study Completion Date
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
APACG. In cases where both eyes are eligible, the right eye will be entered.
IOP less than or equal to 30 mmHg within 24 hours of presentation and after initiation of medical treatment
Significant cataract with best corrected visual acuity equal or less than 6/15
Secondary causes of angle-closure e.g. subluxed lens, uveitis, trauma and neovascular glaucoma
Intumescent cataract (phacomorphic glaucoma)
Eyes with anterior chamber depth differing by more than 0.3 mm
Eyes with no cataract
Active ocular infection in either eye which would prevent surgery
Female subjects who are pregnant, nursing or of childbearing potential and not using adequate contraception
Participating in another study
Previous intraocular eye surgery on the affected eye.
Any medical condition which would be a contra-indication to surgery