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Laser Iridotomy Versus Phacoemulsification in Acute Angle Closure

This study has been completed.
Information provided by:
Singapore National Eye Centre Identifier:
First received: July 7, 2006
Last updated: October 23, 2006
Last verified: October 2004
This is a randomised controlled clinical trial to compare laser peripheral iridotomy (LPI) and primary phacoemulsification with intra-ocular lens implantation (phaco/IOL) in the treatment of acute primary angle-closure glaucoma (APACG). Following successful medical lowering of raised intra-ocular pressure (IOP) and control of intraocular inflammation, patients presenting to Singapore National Eye Centre and Singapore General Hospital with acute primary angle-closure glaucoma who meet the eligibility are randomised to one of the two treatment arms: laser peripheral iridotomy and primary phacoemulsification with intra-ocular lens implantation. These patients will be monitored closely for 2 years post-operatively.

Condition Intervention
Angle Closure Glaucoma Procedure: Laser Preipheral Iridotomy and phacoemulsification

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Angle Closure: Laser Iridotomy Versus Phacoemulsification Study (ACLIPS)- A Study of Acute Primary Angle Closure Glaucoma Comparing Two Treatment Modalities: Laser Peripheral vs Phacoemulsification With Posterior Intraocular Lens Implant

Resource links provided by NLM:

Further study details as provided by Singapore National Eye Centre:

Primary Outcome Measures:
  • Recurrence of APACG: Patients who develop a recurrence of symptoms of APACG. Treatment of recurrence will be decided by the ophthalmologist managing the patient.
  • IOP lowering medication is required.
  • Further glaucoma surgery is required.

Secondary Outcome Measures:
  • Cataract surgery is required. Patients in the LPI group who develop significant progression of cataract during the follow-up period will be offered cataract extraction.
  • No light perception
  • Eyes become phthisical

Estimated Enrollment: 70
Study Start Date: October 2001
Estimated Study Completion Date: October 2007
  Show Detailed Description


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. APACG. In cases where both eyes are eligible, the right eye will be entered.
  2. IOP less than or equal to 30 mmHg within 24 hours of presentation and after initiation of medical treatment
  3. Significant cataract with best corrected visual acuity equal or less than 6/15
  4. Informed consent

Exclusion Criteria:

  1. Secondary causes of angle-closure e.g. subluxed lens, uveitis, trauma and neovascular glaucoma
  2. Intumescent cataract (phacomorphic glaucoma)
  3. Eyes with anterior chamber depth differing by more than 0.3 mm
  4. Eyes with no cataract
  5. Active ocular infection in either eye which would prevent surgery
  6. Female subjects who are pregnant, nursing or of childbearing potential and not using adequate contraception
  7. Participating in another study
  8. Previous intraocular eye surgery on the affected eye.
  9. Any medical condition which would be a contra-indication to surgery
  Contacts and Locations
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Please refer to this study by its identifier: NCT00350428

Singapore National Eye Centre
Singapore, Singapore, 168751
Sponsors and Collaborators
Singapore National Eye Centre
Principal Investigator: Steve Seah, FRCS (Ed) Singapore National Eye Centre
  More Information Identifier: NCT00350428     History of Changes
Other Study ID Numbers: R221/13/2001
Study First Received: July 7, 2006
Last Updated: October 23, 2006

Keywords provided by Singapore National Eye Centre:
Acute primary angle closure
Laser preipheral iridotomy

Additional relevant MeSH terms:
Glaucoma, Angle-Closure
Ocular Hypertension
Eye Diseases processed this record on August 16, 2017