The Effect of High Dose Vitamin C in Burn Patients (Vitamin C)
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ClinicalTrials.gov Identifier: NCT00350077
Recruitment Status :
(Inadequate resources to submit for approval)
The purpose of this study is to see if intravenous Vitamin C will decrease the amount of IV fluids needed following burn injury in the first 48 hours.
Condition or disease
Drug: Intravenous Vitamin CDrug: Vitamin C
Adequate fluid resuscitation in burn injured patients to allow adequate renal blood flow has been the hallmark of burn care in the last 50 years. The danger of exceeding the optimal intravenous fluid resuscitation has resulted in severe complications including abdominal compartment syndrome, loss of upper airway control, extremity compartment syndromes and pulmonary edema. Hig dose vitamin C infusion during the first 24 hours of burn resuscitation has been documented to decrease the overall amount of intravenous fluid needed to provide for adequate renal perfusion and hemodynamic stability in multiple animal model studies. High dose vitamin C is thought to decrease postburn microvascular protein and fluid leakage by reducing postburn lipid oxygenation caused by burn injury generated free radicals.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 72 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
>/= 20% total body surface area full and partial thickness burns
Admitted to the USAISR burn center within 10 hours post injury
Pregnant or breast feeding
Documented preadmission or admission renal failure
History of glucose-6-phosphate dehydrogenase deficiency, kidney stoves, gout or sickle cell
Renal replacement of any kind<24 hours after admission