Spatial Neglect and Bias in Near and Far Space

Study Description

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Brief Summary:

The purpose of this research study is to learn how people distribute their visual attention when looking at objects nearby versus far away, and why vision may become distracted at near versus far distances.

Condition or disease
Stroke

Detailed Description:

Visual distraction is a problem that more often occurs people who have suffered strokes than in the general population. Problems of visual attention generally appear immediately following a stroke, and may impair driving and other functions. While it is thought that there is a natural course of improvement over time, little is known about how this improvement occurs. Some studies suggest that recovery is only partial, meaning certain aspects of visual attention may improve while other aspects remain but escape notice.

The purpose of this study is to examine the effect of stroke on a person's visual attention when looking at objects nearby versus far away, and to learn why a person's visual attention may become more distracted at near versus far distances. The purpose of this study is also to understand how modeled interventions, such as eye patching or prism goggles, affect impairment measures of visual attention.

After an initial screening (including attention, thinking, memory, and visual judgment tests), participants will be given a neurological examination. Participants may be asked to perform visual tasks while wearing an eye patch or prism goggles. Next, they will be asked to perform a line bisection task by looking at lines on a video screen either at close or far distances and, using a laser pointer, marking the center of the lines as they appear on-screen. Participants may be asked to perform other, similar visual tasks as well.

Duration of the study for participants varies, ranging from 1 or 2 sessions totaling approximately 2 hours to multiple sessions spanning a year.

Research from this study may help researchers better understand problems associated with stroke and may lead to therapies designed to promote improved visual attention.

Study Design

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Study Type :	Observational
Estimated Enrollment :	950 participants
Observational Model:	Case Control
Time Perspective:	Prospective
Official Title:	Spatial Neglect and Bias in Near and Far Space
Study Start Date :	May 2004
Estimated Primary Completion Date :	April 2017
Estimated Study Completion Date :	April 2018

Groups and Cohorts

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Group/Cohort
1; Persons who have had a stroke
2; Healthy volunteers

Outcome Measures

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :

1. Improve visual attention [ Time Frame: From 1 or 2 sessions totaling approximately 2 hours to multiple sessions in one year ]

Eligibility Criteria

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Ages Eligible for Study:	18 Years and older (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Persons who have had a stroke. Also, healthy volunteers.

Criteria

Inclusion Criteria:

• The subject has a history of stroke.
• The subject is 18 to 100 years old.
• The subject is able to give Informed consent.
• The subject is post-Stroke with left-hemisphere injury and has no spatial neglect (no attentional imbalance).
• The subject is post-stroke with right hemisphere damage and has spatial neglect (attentional imbalance).
• Healthy subject with no brain injury.
• The subject is post stroke and has hemianopia (a "visual field cut").
• The subject is able and willing to comply with the study protocol, including availability for all scheduled clinic visits.

Exclusion Criteria:

• Subjects with brain tumors, head injury with loss of consciousness, visual disorders other than corrected near or far-sightedness, history of learning disabilities, dementia or Alzheimer's Disease.

Contacts and Locations

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Contacts

Contact: Jenny Masmela, BA	(973) 324-3564	jmasmela@kesslerfoundation.org

Locations

United States, New Jersey
Kessler Foundation Research Center, 1199 Pleasant Valley Way	Recruiting
West Orange, New Jersey, United States, 07052
Contact: A M. Barrett, MD 973-324-3569 abarrett@kesslerfoundation.org

Sponsors and Collaborators

Kessler Foundation

National Institute of Neurological Disorders and Stroke (NINDS)

Investigators

Principal Investigator:	Anna M. Barrett, MD	Stroke Rehabilitation Research, Kessler Foundation Research Center

More Information

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Caulfield MD, Chen P, Barry MM, Barrett AM. Which perseverative behaviors are symptoms of spatial neglect? Brain Cogn. 2017 Apr;113:93-101. doi: 10.1016/j.bandc.2016.11.002. Epub 2017 Feb 3.

Responsible Party:	A. M. Barrett, MD, Director, Stroke Research, Kessler Foundation
ClinicalTrials.gov Identifier:	NCT00350012 History of Changes
Other Study ID Numbers:	K02NS047009; 5K02NS047099 ( U.S. NIH Grant/Contract )
First Posted:	July 10, 2006
Last Update Posted:	February 24, 2016
Last Verified:	February 2016

Keywords provided by A. M. Barrett, MD, Kessler Foundation:

stroke; visual; spatial neglect