Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger

This study has been completed.
World Vision
Information provided by:
Johns Hopkins University Identifier:
First received: July 3, 2006
Last updated: October 27, 2011
Last verified: November 2005
There are no specific trials addressing the benefit of water provision and health education on prevalence of trachoma and infection with ocular Chlamydia trachomatis over time, despite considerable effort to provide water resources in trachoma endemic areas. Such information is sorely needed, to advance the Global Alliance agenda for the Elimination of Blinding Trachoma. This community-based clinical trial will randomize ten communities in Maradi Niger, half to receive delivery of water and health education services, and half for delivery of services at a later date. We hypothesize that the intervention communities will have lower rates of trachoma and C. trachomatis one and two years after delivery of services compared to communities without such services. This trial will provide, for the first time, solid evidence of the effect of such services on trachoma, as well as the added benefit following antibiotic provision by the Ministry of Health on sustaining reductions in trachoma and infection.

Condition Intervention Phase
Behavioral: water and health education program to improve hygiene
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Prevention
Official Title: Determination of the Impact of Water and Health Education on Trachoma and Ocular C. Trachomatis in Niger

Resource links provided by NLM:

Further study details as provided by Johns Hopkins University:

Primary Outcome Measures:
  • trachoma
  • ocular C. trachomatis infection

Secondary Outcome Measures:
  • under five years mortality

Estimated Enrollment: 720
Study Start Date: December 2005
Estimated Study Completion Date: January 2008
  Show Detailed Description


Ages Eligible for Study:   6 Months to 65 Months
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • villages size between 900-2100 residents as of 1995 census in Kornaka West district of Niger
  • village leadership approval of entry of village in the study
  • sentinel children ages 6 months to 5 years and five months

Exclusion Criteria:

  • village already has health education program for hygiene
  • village within 5 km of a well
  • child already has a sibling in the study population
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00348478

United States, Maryland
Johns Hopkins University
Baltimore, Maryland, United States, 21205
Sponsors and Collaborators
Johns Hopkins University
World Vision
Principal Investigator: Sheila K West Johns Hopkins University
  More Information

No publications provided Identifier: NCT00348478     History of Changes
Other Study ID Numbers: NA00001455 
Study First Received: July 3, 2006
Last Updated: October 27, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by Johns Hopkins University:
chlamydia trachomatis
health education
face washing

Additional relevant MeSH terms:
Bacterial Infections
Chlamydia Infections
Chlamydiaceae Infections
Conjunctival Diseases
Conjunctivitis, Bacterial
Corneal Diseases
Eye Diseases
Eye Infections
Eye Infections, Bacterial
Gram-Negative Bacterial Infections
Infection processed this record on February 07, 2016