An fMRI Study of Self-regulation in Adolescents With Bulimia Nervosa
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Purpose
The aim of this project is to use both multimodal MRI and behavioral measures to investigate how changes in frontostriatal neural systems contribute to the development and persistence of Bulimia Nervosa (BN). Findings from this study will have wide-ranging importance for our understanding of the development and treatment of BN.
| Condition | Intervention |
|---|---|
|
Eating Disorders |
Other: MRI Behavioral: Neuropsychological Testing |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | An fMRI Study of Self-regulation in Adolescents With Bulimia Nervosa |
- Magnetic resonance imaging scans [ Time Frame: Measured at baseline and follow-up ] [ Designated as safety issue: No ]
- Wechsler Abbreviated Scale of Intelligence (WASI) [ Time Frame: Measured at a single visit ] [ Designated as safety issue: No ]
- Continuous Performance Task [ Time Frame: Measured at baseline and follow-up ] [ Designated as safety issue: No ]
- Stroop Word-Color Interference [ Time Frame: Measured at baseline and follow-up ] [ Designated as safety issue: No ]
- Weather Prediction Task [ Time Frame: Measured at baseline and follow-up ] [ Designated as safety issue: No ]
- Silverman [ Time Frame: Measured at baseline and follow-up ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 80 |
| Study Start Date: | October 2004 |
| Estimated Study Completion Date: | November 2016 |
| Estimated Primary Completion Date: | November 2016 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
1
Adolescents with Bulimia Nervosa or subclinical Bulimia Nervosa
|
Other: MRI
Magnetic Resonance Imaging scans
Other Names:
Behavioral: Neuropsychological Testing
Neuropsychological tests
Other Names:
|
|
2
Healthy control adolescents
|
Other: MRI
Magnetic Resonance Imaging scans
Other Names:
Behavioral: Neuropsychological Testing
Neuropsychological tests
Other Names:
|
Detailed Description:
Patients with Bulimia Nervosa (BN) have difficulty regulating impulsive behaviors as suggested by their binge-eating and purging, as well as the high incidence of drug abuse and shoplifting in this population. Understanding dysfunction in the frontostriatal circuitry that mediates self-regulatory control processes will aid development of new therapeutics for the impulsivity associated with BN. We are conducting a longitudinal study to better understand the development and persistence of BN.
Participation in this study includes 4 sections: Neuropsychological Tests, Diagnostic interviews, Pregnancy Test, and MRI scan. All efforts are made to coordinate procedures into one day, and they require between 4 and 5 hours of the participant's time. The option of splitting participation into two study days is also offered for participants who find it more convenient. Participants are compensated with $100 in the form of a check, which is mailed to their home address. Participants will be invited back for follow-up visits.
Eligibility| Ages Eligible for Study: | 12 Years to 17 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Adolescents (ages 12-17 years) with bulimia nervosa and age, gender, and weight-matched controls
Inclusion Criteria:
- Current or prior DSM IV diagnosis of Bulimia Nervosa or Sub-threshold Bulimia Nervosa (those who meet all DSM-IV criteria for BN, but engage in subjective binge-eating episodes and binge/purge at a frequency of at least once per week for 3 months, whereas meeting full DSM-IV criteria for BN requires binge eating and purging twice per week for 3 months)
- Major Depression
- For control adolescents, no current or past history of an eating disorder
Exclusion Criteria:
- Ferromagnetic implants (e.g., pacemaker)
- Metal braces or retainers
- IQ less than 80
- Any other current major Axis I disorder, other than major depressive disorder (MDD)
- History of concussion, seizure disorder, or other neurological illness
- Claustrophobia
- Pregnant
Contacts and LocationsPlease refer to this study by its ClinicalTrials.gov identifier: NCT00345943
| Contact: Eating Disorders Clinic | 646-774-8066 | edru@nyspi.columbia.edu | |
| Contact: Kate Terranova, BA | 646-774-5868 | terrano@nyspi.columbia.edu |
| United States, New York | |
| New York State Psychiatric Institute at Columbia University Medical Center | Recruiting |
| New York, New York, United States, 10032 | |
| Principal Investigator: | Rachel Marsh, PhD | Columbia University |
More Information
No publications provided by New York State Psychiatric Institute
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | New York State Psychiatric Institute |
| ClinicalTrials.gov Identifier: | NCT00345943 History of Changes |
| Other Study ID Numbers: | #5606R/6679R, R01MH090062, DDTR M2-MBB |
| Study First Received: | June 28, 2006 |
| Last Updated: | August 29, 2014 |
| Health Authority: | United States: Federal Government |
Keywords provided by New York State Psychiatric Institute:
|
Eating Disorders Bulimia Nervosa Bulimia fMRI Magnetic Resonance Imaging |
Additional relevant MeSH terms:
|
Bulimia Nervosa Eating Disorders Mental Disorders |
ClinicalTrials.gov processed this record on March 01, 2015